Anti-Mouse CD120b (TNFR2) (Clone TR75-54.7) – DyLight® 488

Anti-Mouse CD120b (TNFR2) (Clone TR75-54.7) – DyLight® 488

Product No.: T627

[product_table name="All Top" skus="T627"]

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Clone
TR75-54.7
Target
TNFR2
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
TNFRSF1B, p75, CD120b, TBPII, TNF-R75, TNFBR, TNFR2, TNFR80, p75TNFR
Isotype
IgG
Applications
FC

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Product Size
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Antibody Details

Product Details

Reactive Species
Mouse
Host Species
Armenian Hamster
Immunogen
E. coli -expressed mouse Type II TNFR
Product Concentration
0.2 mg/ml
Formulation
This DyLight® 488 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Handling
This DyLight® 488 conjugate is stable when stored at 2-8°C. Do not freeze.
Country of Origin
USA
Shipping
Next Day 2-8°C
Excitation Laser
Blue Laser (493 nm)
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Armenian Hamster Anti-Mouse Tumor Necrosis Factor Receptor II (TNF RII) (Clone TR75-54.7) recognizes an epitope on Mouse TNF RII. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Background
Tumor necrosis factor receptor II (TNF-RII) or CD120b is a 75kD type I transmembrane protein present on most cell types at low levels1 including endothelial cells, cardiac myocytes and prostate cells2; the expression is upregulated upon activation. This receptor binds both TNF-α & TNF-β (aka. LT-α). In association with TRAF1 and TRAF2, the receptor crosslinking induced by TNF-α or LT-α trimers is critical for signal transduction, leading to apoptosis, NF-kB activation, increased expression of proinflammatory genes, tumor necrosis, and cell differentiation depending on cell type and differentiation state. The TR75-54.7 antibody has been shown to block ligand-induced receptor signaling.

Antigen Details

PubMed
NCBI Gene Bank ID
Research Area
Immunology
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Innate Immunity

References & Citations

1. Zuckerman, KS. et al. (1998) Cancer Res. 58: 2217
2. Chan, FKM. et al. (2000) Science 288:2351
3. Loetscher, H. et al. (1990) Cell 61:351
4. Rothe, J. et al. (1993) Nature 364:798
Flow Cytometry
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Formats Available

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Products are for research use only. Not for use in diagnostic or therapeutic procedures.