Anti-Neuroligin-3 Antibody (56552)

Fusion protein corresponding to aa 730-848 (intracellular C-terminus) of rat Neuroligin- 3. This sequence is 99

PBS, pH 7.4, 0.1% sodium azide, 50% glycerol.

Liquid

Purified by Protein G affinity chromatography

This product is stable for at least one (1) year at -20°C.

For in vitro investigational use only. Not intended for therapeutic or diagnostic procedures.

Next Day 2-8°C

This antibody recognizes human, mouse and rat Neuroligin-3. It does not cross-react with Neuroligin-1, -2, or -4.

Neuroligin-3 is a neuronal cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. It plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. It may also promote the initial formation of synapses and play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system. {PubMed:17897391}.