Anti-NPFF2 Antibody (56111)

Product No.: 56111

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Target
NPFF2
Product Type
Polyclonal
Alternate Names
G-protein coupled receptor 74, G-protein coupled receptor HLWAR77, Neuropeptide G-protein coupled receptor
Isotype
Rabbit
Applications
WB,ELISA

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Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
N-terminal sequence MNEKWDTNSSENWHPI and C-terminal sequence ELVMEELKETTNSSEI of human NPFF2.
Product Concentration
Lot Specific
Formulation
PBS, pH 7.4 with 0.02% sodium azide
State of Matter
Liquid
Product Preparation
Purified by immunoaffinity chromatography
Storage and Handling
This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.
Country of Origin
USA
Shipping
Next Day 2-8°C
Applications and Recommended Usage?
Quality Tested by Leinco
Immunoblotting: use at 1:500-1:1,000 dilution

ELISA: use at 1:1,000-1:5,000 dilution.
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Polyclonal Antibody specific to NPFF2
Background
The central nervous system octapeptide, neuropeptide FF (NPFF), is believed to play a role in pain modulation and opiate tolerance. Two G protein-coupled receptors, NPFF1 and NPFF2, have been isolated from human and rat central nervous system tissues. Localization of mRNA and binding sites of these receptors in the dorsal horn of the spinal cord, the lateral hypothalamus, the spinal trigeminal nuclei, and the thalamic nuclei suggest a role for NPFF in pain modulation.

Antigen Details

Function
Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
NCBI Gene Bank ID
UniProt.org
Research Area
Neuroscience

References & Citations

WB,ELISA
Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.