Anti-Rabies Virus Antibody (20501)
Anti-Rabies Virus Antibody (20501)
Product No.: 20501
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Clone RV1C5 Target Rabies Virus Formats AvailableView All Product Type Monoclonal Isotype Mouse IgG2a Applications ELISA , IF , IHC |
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Antibody DetailsProduct DetailsReactive Species Rabies Virus Host Species Mouse Immunogen Purified rabies virus, Russian vaccine strain Vnukovo 32 Product Concentration Lot Specific Formulation PBS, pH 7.4, 0.09% sodium azide. State of Matter Liquid Product Preparation Purified by Protein G affinity chromatography Storage and Handling This antibody is stable for at least one (1) year at 4°C. Regulatory Status Research Use Only Country of Origin USA Shipping Next Day 2-8°C Applications and Recommended Usage? Quality Tested by Leinco ELISA Immunofluorescence
Immunohistochemistry Customer confirmed that #20501 works on formalin-fixed tissues with protease pre-treatment Immunoblotting Customer confirmed that #20501 detects viral glycoprotein in Western blot. End users should determine optimal antibody concentrations for their applications. Additional Applications Reported In Literature ? ELISA, IHC, IF Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity This antibody recognizes rabies virus glycoprotein (UniProtKB Q08089) and neutralizes the following strains of rabies virus: CVS, Flury Lep, Flury HEP, Mokola 1, Mokola 2, Lagos bat, Duvenhage, and field isolates. Background Rabies is a zoonotic infectious disease of the central nervous system. In unvaccinated or untreated subjects, rabies virus infection causes severe neurological symptoms and is usually fatal. Rabies virus has a bullet-shaped, enveloped virion with a negative-sense single-stranded RNA genome that encodes five viral proteins: nucleoprotein, phosphoprotein, matrix protein, glycoprotein, and RNA-dependent RNA polymerase. The virus attaches to its cellular targets by the surface glycoprotein (RABV-G), rapidly gains access to peripheral nerves, and ultimately reaches the brain. Transport of the enveloped virus within nerve cells and neuronal transport vesicles impedes clearance by humoral or cellular immunity. Research Area Infectious Disease References & CitationsTechnical ProtocolsCertificate of Analysis |
Formats Available
