Anti-Rabies Virus Antibody (20501)

Anti-Rabies Virus Antibody (20501)

Product No.: 20501

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Clone
RV1C5
Target
Rabies Virus
Formats AvailableView All
Product Type
Monoclonal
Isotype
Mouse IgG2a
Applications
ELISA
,
IF
,
IHC

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Select Product Size
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Antibody Details

Product Details

Reactive Species
Rabies Virus
Host Species
Mouse
Immunogen
Purified rabies virus, Russian vaccine strain Vnukovo 32
Product Concentration
Lot Specific
Formulation
PBS, pH 7.4, 0.09% sodium azide.
State of Matter
Liquid
Product Preparation
Purified by Protein G affinity chromatography
Storage and Handling
This antibody is stable for at least one (1) year at 4°C.
Regulatory Status
Research Use Only
Country of Origin
USA
Shipping
Next Day 2-8°C
Applications and Recommended Usage?
Quality Tested by Leinco
ELISA Immunofluorescence

Immunohistochemistry Customer confirmed that #20501 works on formalin-fixed tissues with protease pre-treatment

Immunoblotting Customer confirmed that #20501 detects viral glycoprotein in Western blot.

End users should determine optimal antibody concentrations for their applications.
Additional Applications Reported In Literature ?
ELISA,
IHC,
IF
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Description

Specificity
This antibody recognizes rabies virus glycoprotein (UniProtKB Q08089) and neutralizes the following strains of rabies virus: CVS, Flury Lep, Flury HEP, Mokola 1, Mokola 2, Lagos bat, Duvenhage, and field isolates.
Background
Rabies is a zoonotic infectious disease of the central nervous system. In unvaccinated or untreated subjects, rabies virus infection causes severe neurological symptoms and is usually fatal. Rabies virus has a bullet-shaped, enveloped virion with a negative-sense single-stranded RNA genome that encodes five viral proteins: nucleoprotein, phosphoprotein, matrix protein, glycoprotein, and RNA-dependent RNA polymerase. The virus attaches to its cellular targets by the surface glycoprotein (RABV-G), rapidly gains access to peripheral nerves, and ultimately reaches the brain. Transport of the enveloped virus within nerve cells and neuronal transport vesicles impedes clearance by humoral or cellular immunity.
Research Area
Infectious Disease

References & Citations

Indirect Elisa Protocol
IF
IHC

Certificate of Analysis

Formats Available

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Prod No.
Description
20501
Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.