Anti-RAD17 Antibody (56229)
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Antibody DetailsProduct DetailsReactivity Species Human Host Species Rabbit Immunogen Peptide corresponding to aa 2-15 of human RAD17. Product Concentration Lot Specific Formulation PBS, pH 7.4 with 0.02% sodium azide State of Matter Liquid Product Preparation Purified by peptide immuno-affinity chromatography Storage and Handling This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles. Country of Origin USA Shipping Next Day 2-8°C Applications and Recommended Usage? Quality Tested by Leinco Immunoblotting: use at 1:500-1:1,000 dilution. A band of approx. 69 kD is detected. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity Rabbit Polyclonal Antibody specific to RAD17 Background RAD17 is a novel gene product involved
in the DNA damage checkpoint signal
transduction pathway. RAD17 plays a
central role in cell cycle checkpoint
control. Antigen DetailsFunction Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous rPubMed:10208430, PubMed:11418864, PubMed:11687627, PubMed:11799063, PubMed:12578958, PubMed:12672690, PubMed:14500819, PubMed:14624239, PubMed:15235112, PubMed:15538388, PubMed:21659603}. NCBI Gene Bank ID UniProt.org Research Area Cancer Research References & CitationsTechnical Protocols |
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
