Anti-Rat TIMP-1 (Clone 150906)
Anti-Rat TIMP-1 (Clone 150906)
Product No.: T445
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Clone 150906 Target TIMP-1 Formats AvailableView All Product Type Monoclonal Antibody Alternate Names EPO, CLGI, EPA, FLJ90373, HCI, TIMP, Tissue Inhibitor of Metalloproteinase 1 Isotype IgG1 Applications IP |
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Antibody DetailsProduct DetailsReactive Species Rat Host Species Mouse Immunogen NS0-Derived Recombinant Rat TIMP-1 Formulation This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present. Storage and Handling The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months. Country of Origin USA Shipping Next Day Ambient RRIDAB_2831945 Additional Applications Reported In Literature ? Immunoprecipitation: This antibody was used at 25 μg/mL to immunoprecipitaterrTIMP-1 from conditioned cell culture media. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Mouse Anti-Rat Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) (Clone 150906) recognizes an epitope on Rat TIMP-1. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. Background Tissue Inhibitor of Metalloproteinases 1, also known as TIMP1 is a widely expressed, secreted protein that functions primarily to inhibit members of a large family of metalloproteinases (MPs). Because of the ability of TIMP-1 to inhibit MPs, it functions in many of the same pathophysiological processes as these enzymes, e.g. wound healing, ovulation, angiogenesis, and cancer cell metastasis. TIMP-1 can also stimulate proliferation and cellular anabolic processes.1 TIMP-1 is a novel negative regulator of HGF activity during liver regeneration.2 Overexpression of TIMP-1 could promote renal interstitial fibrosis through the inflammatory pathway, which might be partly induced by upregulating ICAM-1.3 PubMed NCBI Gene Bank ID UniProt.org References & Citations1. Denhardt, DT.et al. (2005) Breast Cancer Res Treat. 94: 185 2. Khokha, R. et al. (2005) Hepatology 41: 857 3. Chen, X. et al. (2008) Nephrology Dialysis Transportation 23: 1861 Technical ProtocolsCertificate of Analysis |
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