Anti-Sin Nombre Virus (Hantavirus) (Clone: SNV-53)
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Antibody DetailsProduct DetailsReactive Species Hantavirus ⋅ Sin Nombre ⋅ Virus Expression Host HEK-293 Cells Immunogen Sequenced from human survivors of Sin Nombre. Product Concentration ≥ 5.0 mg/ml Endotoxin Level < 1.0 EU/mg as determined by the LAL method Purity ≥95% monomer by analytical SEC Formulation This recombinant monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration. Product Preparation Recombinant antibodies are manufactured in an animal free facility using only in vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates. Storage and Handling Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one year. For longer term storage, aseptically aliquot in working volumes without diluting and store at ≥ -70°C. Avoid Repeated Freeze Thaw Cycles. Country of Origin USA Shipping Standard Overnight on Blue Ice. Additional Applications Reported In Literature ? ELISA N Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity SNV-53 specificity is directed against the surface glycoprotein spike.
Background Hantavirus is an enveloped, negative-sensed, single-stranded RNA virus in the bunyavirus family1. “New World” hantaviruses (NWH) are found in the Americas and may cause hantavirus pulmonary syndrome (HPS)2. “Old World” hantaviruses (OWH) are found mostly in Europe and Asia and may cause hemorrhagic fever with renal syndrome. Each hantavirus serotype has a specific rodent host species and infection is spread by aerosolized urine, feces, saliva, or by rodent bites. Sin Nombre Virus (SNV), a NWH first isolated from rodents in the Southwestern United States, infects with a mortality rate of 50%1. The probability of survival for Syrian hamsters infected with SNV significantly increases when treated postinfection with the monoclonal antibody (mAb) SNV-533.
Antigen DetailsResearch Area Category A Pathogens . Infectious Disease . Sin Nombre . Viral References & Citations1. Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Division of High-Consequence Pathogens and Pathology (DHCPP), Link Text
2. Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Division of High-Consequence Pathogens and Pathology (DHCPP), Link Text 3. Engdahl TB, Kuzmina NA, Ronk AJ, et al. Cell Rep. 35(5):109086. 2021. Technical Protocols N |
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