Anti-Sin Nombre Virus, Glycoprotein (Hantavirus) (Clone SNV-39) – Purified No Carrier Protein

Anti-Sin Nombre Virus, Glycoprotein (Hantavirus) (Clone SNV-39) – Purified No Carrier Protein

Product No.: H289

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Product No.H289
Clone
SNV-39
Target
Sin Nombre Virus
Glycoprotein
Formats AvailableView All
Product Type
Recombinant Monoclonal Antibody
Alternate Names
SNV, Hantavirus, Gn/Gc, GP, OWH, NWH
Isotype
Human IgG1
Applications
ELISA
,
N

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Antibody Details

Product Details

Reactive Species
Sin Nombre
Expression Host
HEK-293 Cells
Immunogen
Sequenced from PBMCs from a donor who had recovered from a naturally-occurring Sin Nombre Virus infection.
Product Concentration
≥1.0 mg/ml
Purity
≥90% monomer by analytical SEC and SDS-Page
Formulation
This recombinant monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
State of Matter
Liquid
Product Preparation
Recombinant antibodies are manufactured in an animal free facility using only in vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling
Antibodies may be stored sterile as received at 2-8°C for up to one year. For longer term storage, aseptically aliquot in working volumes without diluting and store at ≥ -80°C. Avoid Repeated Freeze Thaw Cycles.
Regulatory Status
Research Use Only
Country of Origin
USA
Shipping
2 – 8° C Wet Ice
Additional Applications Reported In Literature ?
ELISA,
N
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Description

Specificity
The SNV-39 monoclonal antibody is specific for the glycoprotein complex (Gn/Gc) of the Sin Nombre virus (SNV). It is also capable of binding and neutralizing many OWH isolates.
Background
Hantavirus is an enveloped, negative-sensed, single-stranded RNA virus in the bunyavirus family. “New World” hantaviruses (NWH) are found in the Americas and may cause hantavirus pulmonary syndrome (HPS). “Old World” hantaviruses (OWH) are found mostly in Europe and Asia and may cause hemorrhagic fever with renal syndrome. Each hantavirus serotype has a specific rodent host species and is spread by aerosolized urine, feces, saliva, or rodent bites. Sin Nombre Virus (SNV), a NWH first isolated from rodents in the Southwestern United States, infects with a mortality rate of 50%1.

SNV-39 specifically targets the glycoprotein complex (Gn/Gc) of SNV, which are essential for the virus's entry into host cells. The antibody binds to these proteins, thereby inhibiting the virus's ability to attach and fuse with the host cell membranes. This neutralizing activity makes SNV-39 a valuable tool in both therapeutic and diagnostic applications2.
Antigen Distribution
Hantavirus infects and replicates in pulmonary and cardiac endothelium in both humans and deer mice, the natural host.
Research Area
Category A Pathogens
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Infectious Disease
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Viral
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IVD Raw Material

References & Citations

1. CDC. About Hantavirus. Hantavirus. Published June 4, 2024. Accessed June 17, 2024. https://www.cdc.gov/hantavirus/about/index.html
2. Engdahl TB, Binshtein E, Brocato RL, et al. Antigenic mapping and functional characterization of human New World hantavirus neutralizing antibodies. Elife. 2023;12:e81743.
Indirect Elisa Protocol
N

Certificate of Analysis

Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.