Anti-West Nile Virus Envelope Protein (Intermediate Domain) (WNV Env)

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Pricing & Details

Product No.W146
Protein
West Nile Virus Envelope Protein
Formats AvailableView All
Product Type
Polyclonal Antibody
Applications
ELISA Indirect
Prod No.
Size
Price
Avail.
Qty
Add to cart
W146-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
W146-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Antibody Details

Product Details

Reactivity Species
Virus
Host Species
Rabbit
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-West Nile Virus Envelope Protein (WNV Env) recognizes an epitope in the intermediate domain of WNV Env. This polyclonal antibody was purified using affinity chromatography.
Background
West Nile Virus (WNV) is a member of the Flaviviridae, a plus-stranded virus family that includes St. Louis encephalitis virus, yellow fever virus, and Dengue virus. WNV was initially isolated in 1937 in the West Nile region of Uganda and has become prevalent in Africa, Asia, and Europe. It has rapidly spread across the United States with cases being observed in every continental state (reviewed in 1). Virus particles consist of a dense core made up of the core/capsid protein encapsulating the RNA genome surrounded by a membrane envelope embedded with envelope and matrix proteins.1 While the viral core protein is thought to contribute to the WNV-associated inflammation via apoptosis induced though the caspase-9 pathway,2 the highly glycosylated envelope protein plays a major role for WNV entry into target cells as this entry can be inhibited by using a recombinant domain III from the envelope glycoprotein.3 The WNV receptor has recently been identified as alpha v beta 3 integrin.4

Antigen Details

References & Citations

1. Gould, L. H. et al. (2004) J. Clin. Invest. 113:1102 2. Yang, J. S. et al. (2002) Emerg. Infect. Dis. 8:1379 3. Chu, J. J. et al. (2005) J. Gen. Virol. 86:405 4. Chu, J. J. et al. (2004) J. Biol. Chem. 279:54533
Indirect Elisa Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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