Recombinant Human Epidermal Growth Factor
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Antibody DetailsProduct DetailsReactive Species Human Formulation EGF was lyophilized from a concentrated (1 mg/ml) solution containing PBS pH-7.4. State of Matter Lyophilized Storage and Handling This lyophilized protein should be stored desiccated at -20°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for 2 - 7 days or at -20°C for longer term. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze- thaw cycles. Country of Origin USA Shipping Next Day 2-8°C Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Recombinant Epidermal Growth Factor Background Epidermal Growth Factor (EGF) is a 6-kDa protein consisting of 53 amino acid residues and 3 intramolecular disulfide linkages. Human tissues, such as platelets, the parotid gland, and the submandibular gland, are rich in EGF. EGF, which was first discovered in human urine and the submaxillary glands of mice, functions as a major modulator of cell proliferation by attaching to its receptor, EGFR, which is found on the cell membrane. EGF triggers autophosphorylation of transmembrane protein tyrosine kinase EGFR upon binding, hence initiating downstream signaling cascades through pathways such as phosphatidylinositol and ras. Beyond the cell membrane, EGF has a variety of roles as it also initiates cytoplasmic processes such actin depolymerization and membrane ruffle formation. Studies indicate that EGF and its receptor might possibly be important components of the nucleus, highlighting the complexity of EGF-mediated cellular responses. References & CitationsTechnical Protocols Certificate of Analysis |
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