Hsp27 (11110P)
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Antibody DetailsProduct DetailsReactive Species Human Product Concentration Lot Specific Formulation Sterile-filtered colorless solution in 20mM HEPES, pH 7.5, 1mM DTT, and 100mM KCl. State of Matter Liquid Storage and Handling Although stable at 4°C for 1 week, product is best stored at or below -20°C. Addition of a carrier protein (such as 0.1% HSA or BSA) is recommended for long-term storage. Country of Origin USA Shipping Next Day 2-8°C Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Recombinant Human Hsp27 Background Hsp27, a mammalian heat shock protein, is expressed constitutively in many tissues, and its expression level increases in response to various stress conditions including elevated temperatures, toxic metals, drugs, and oxidants. Hsp27 is phosphorylated in vivo at three phosphorylation sites (Ser15, Ser78, and Ser82) by protein kinases including MAPKAP kinase 2 and stress-activated protein kinase SAPK2. Function Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (PubMed:10383393, PubMed:20178975). Plays a role in stress resistance and actin organization (PubMed:19166925). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (PubMed:23728742). {PubMed:10383393, PubMed:19166925, PubMed:20178975, PubMed:23728742}. References & CitationsTechnical Protocols Certificate of Analysis |
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
