IL-31 (Intermediate Domain) Blocking Peptide

18 amino acids near the center of human IL31.

This peptide is formulated in PBS pH 7.2 (0.01 M Sodium Phosphate, 0.13 M NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide.

Store this peptide in working aliquots at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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18 amino acids near the center of human IL31.

Interleukin-31 (IL-31) is a T-cell cytokine, which is preferentially produced by type 2 helper T cells. The structure of IL-31 places it in the IL-6 family of cytokines. IL-31 signals via a receptor complex that is composed of IL-31 receptor A and oncostatin M receptor subunits. IL-31 is believed to play a role in inflammation of the skin.¹ IL-31 represents a novel target for antipruritic drug development.²

1. Stacey R Dillon et al.(2004) Nature Immunol. 5: 752 2. Homey B. et al.(2006) J Allergy Clin Immunol. 117: 411