Mn Superoxide Dismutase (13003P)
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Antibody DetailsProduct DetailsReactive Species Human Product Concentration Lot Specific Formulation Sterile-filtered solution in 20mM Tris-HCl, pH 8.0, 20% glycerol. State of Matter Liquid Storage and Handling Store at 4°C if entire vial will be used within 2-4 weeks. Store at -20°C for longer periods of time. Addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Avoid multiple freeze-thaw cycles. Country of Origin USA Shipping Next Day 2-8°C Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Recombinant Human Mn Superoxide Dismutase Background SOD2 is part of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. SOD2 binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in SOD2 gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. SOD2 destroys radicals which are usually produced within the cells and which are toxic to biological systems. Function Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. {PubMed:10334867}. References & CitationsTechnical Protocols Certificate of Analysis |
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