Neurturin Blocking Peptide
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Antibody DetailsProduct DetailsReactive Species Human Product Concentration 0.2 mg/ml Amino Acid Location This peptide sequence is located at amino acids 178 to 193 of Human Neurturin protein. Formulation This peptide is formulated in PBS pH 7.2 (0.01 M Sodium Phosphate, 0.13 M NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide. Storage and Handling Store this peptide in working aliquots at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. Country of Origin USA Shipping Next Day Ambient Amino Acid Sequence 16 amino acids of human NTN. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. Background Neurturin (NRTN) is a potent neurotrophic factor.1 NRTN supports the survival of cultured sympathetic neurons and sensory neurons of the nodose and dorsal root ganglia. Neurturin is structurally related to GDNF (Glial cell line-derived neurotrophic factor).2 NRTN has been demonstrated to act specifically on mesencephalic dopaminergic neurons, suggesting its therapeutic potential for Parkinson's disease (PD).3 Antigen DetailsReferences & Citations1. Jeffrey Milbrandt et al. (1997) Genomics 44: 137
2. Kotzbauer et al. (1996) Nature 384: 467
3. Sheng-Di Chen et al. (2007) Molec. Neurodegeneration 2: 19
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.
