Fibroblast growth factor 19, also known as FGF19 is an atypical member of the fibroblast growth factor (FGF) family of proteins. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF19 uniquely binds to FGF receptor 4 (FGFR4).1 The FGF19 subfamily has reduced heparin binding resulting from a disrupted beta-trefoil domain. Reduced heparin binding allows these FGFs to diffuse beyond their site of origin and act as endocrine hormones. This family of FGFs is regulated, at least in part, by nuclear hormone receptors.2 Inactivation of FGF19 could be beneficial for the treatment of colon cancer, liver cancer and other malignancies involving interaction of FGF19 and FGFR4.3
>97% by SDS-PAGE and analyzed by silver stain.
<0.1 EU/µg as determined by the LAL method
The biological activity of Human FGF-19 was determined by its ability to bind rhFGF R4/Fc in a functional ELISA. Immobilized rhFGF R4/Fc at 2 μg/mL (100 μL/well) can bind rhFGF-19 with a linear range of 3 - 100 ng/mL.
Protein Accession No.
Amino Acid Sequence
lafsdagphv hygwgdpirl rhlytsgphg lsscflrira dgvvdcargq sahslleika valrtvaikg vhsvrylcmg adgkmqgllq yseedcafee eirpdgynvy rsekhrlpvs lssakqrqly knrgflplsh flpmlpmvpe epedlrghle sdmfssplet dsmdpfglvt gleavrspsf ek
N-terminal Sequence Analysis
State of Matter
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human FGF-19 is Mr 21 kDa.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
Next Day Ambient
NCBI Gene Bank
References & Citations
1. French, DM. et al. (2008) Cancel Res. 68: 5086
2. Jones, S. et al. (2008) Mol Pharm. 5: 42
3. French, DM. et al. (2008) Oncogene 27: 85
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.