Recombinant Human IL-17 R

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Pricing & Details

Product. No.I-540
Alternate Names
Interleukin-17 Receptor, IL17R, CDw217, IL-17RA, IL17RA, MGC10262
Expression Host
NS0 cells
Species
Human
Prod No.
Size
Price
Avail.
Qty
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I-540-100 µg
100 µg
$369.00
In stock
Max:
Min: 1
Step: 1

Background

Interleukin-17 receptor (IL-17R) Type 1 transmembrane glycoprotein which binds interleukin 17. IL-17R signaling is critical for pulmonary neutrophil recruitment and host defense against Gram-negative bacteria.1 It represents a marker for the metastasizing ability of osteosarcoma.1

Protein Details

Purity
>95% by SDS Page and analyzed by silver stain.
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Biological Activity
The biological activity of Human IL-17R was determined by its ability to inhibit IL-17-induced IL-6 production by NHDF cells. The ED50 for this effect is typically 0.03 - 0.1 μg/ml in the presence of 10 ng/ml rhIL-17.
Expression Host
NS0 cells
Protein Accession No.
Amino Acid Sequence
The DNA sequence encoding the human IL-17 R extracellular domain protein sequence (Yao, Z., et al., (1997) Cytokine 9(11):794 - 800) was fused to the Fc region of human IgG1 via a polypeptide linked, inserted into a suitable mammalian expression vector and expressed in NSO cells.
N-terminal Sequence Analysis
Leu33
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human IL-17R is Mr 60 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 100 kDa.
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
PubMed
NCBI Gene Bank

References & Citations

1. Facchini, A. et al. (2007) J clin. Research clin. oncol. 133: 1017
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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