Recombinant Human Interleukin-17 receptor (IL-17 R)

Recombinant Human Interleukin-17 receptor (IL-17 R)

Product No.: I-552

[product_table name="All Top" skus="I-552"]

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Alternate Names
Interleukin-17 Receptor, CD217, CDw217, IL-17RA, MGC10262, hIL-17R
Product Type
Recombinant Protein
Expression Host
NS0 Cells

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Select Product Size
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Interleukin-17 receptor (IL-17R), also known as CD217, is a cytokine receptor which binds interleukin-17 (1). Functional IL-17R is a heteromeric complex consisting of at least IL17RA and IL17RC (2). IL-17R is expressed on a wide range of hematopoietic and non-hematopoietic tissues and cell lines, as well as cord blood lymphocytes, peripheral blood lymphocytes and thymocytes. Expression is also on B, T and NK cells, fibroblasts, epithelial cells, monocytes, macrophages and granulocytes. IL-17R signaling is critical for pulmonary neutrophil recruitment and host defense against Gram-negative bacteria through the coordinated release of G-CSF and CXC chemokine elaboration (3). IL-17/IL-17R play a critical role in regulating host susceptibility to Chlamydia infection in mice (4).

Protein Details

>95% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Fusion Protein Tag
Fc Fusion Protein
Protein Accession No.
Amino Acid Sequence
lrlldhra lvcsqpglnc tvknstcldd swihprnltp sspkdlqiql hfahtqqgdl fpvahiewtl qtdasilyle gaelsvlqln tnerlcvrfe flsklrhhhr rwrftfshfv vdpdqeyevt vhhlpkpipd gdpnhqsknf lvpdceharm kvttpcmssg slwdpnitve tleahqlrvs ftlwnesthy qilltsfphm enhscfehmh hipaprpeef hqrsnvtltl rnlkgccrhq vqiqpffssc lndclrhsat vscpempdtp epipdymplw iegrmdpksc dkthtcppcp apellggpsv flfppkpkdt lmisrtpevt cvvvdvshed pevkfnwyvd gvevhnaktk preeqynsty rvvsvltvlh qdwlngkeyk ckvsnkalpa piektiskak gqprepqvyt lppsrdeltk nqvsltclvk gfypsdiave wesngqpenn ykttppvlds dgsfflyskl tvdksrwqqg nvfscsvmhe alhnhytqks lslspgk
N-terminal Sequence Analysis
State of Matter
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human IL-17 R is Mr 60 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 100 kDa.
Predicted Molecular Mass
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
Next Day Ambient
NCBI Gene Bank

References & Citations

1. Yao, Z. et al. (1997) Cytokine 9:794
2. Toy, D. et al. (2006) J. Immunol. 177:36
3. McAlister, F. et al. (2005) J. Immunol. 175:404
4. Wang, J. et al. (2009) Infect. Immun. 77:5059
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.