Recombinant Human IL-18 Rα

Recombinant Human IL-18 Rα

Product No.: I-591

[product_table name="All Top" skus="I-591"]

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Alternate Names
Interleukin-18 Receptor Alpha, IL18R1, CDw218a, IL-1Rrp, IL1RRP
Product Type
Recombinant Protein
Expression Host
NS0 Cells

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Select Product Size
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The interleukin-18 receptor 1 (IL-18R1) is a cytokine receptor of the immunoglobulin superfamily. IL18R1 is also known as IL-18Rα, CDw218a (cluster of differentiation w218a), IL-1Rrp, and IL-1R family member. IL-18R1 specifically binds to interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IL-18Rα is expressed on Th1 cells, NK cell subset, neutrophils and IL-12-stimulated tonsillar B cells. By itself, IL-18Rα binds IL-18 with low affinity and when complexed with IL-18Rβ chain binds IL-18 with high affinity. The proinflammatory cytokine IL-18 and its receptor complex play an important role in the innate and autoimmune responses.

Protein Details

>95% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<1.0 EU/µg as determined by the LAL method
Fusion Protein Tag
Fc Fusion Protein
Protein Accession No.
Amino Acid Sequence
e sctsrphitv vegepfylkh cscslaheie tttkswykss gsqehvelnp rsssrialhd cvlefwpvel ndtgsyffqm knytqkwkln virrnkhscf terqvtskiv evkkffqitc ensyyqtlvn stslyknckk lllennknpt ikknaefedq gyyscvhflh hngklfnitk tfnitivedr snivpvllgp klnhvavelg knvrlncsal lneedviywm fgeengsdpn iheekemrim tpegkwhask vlrieniges nlnvlynctv astggtdtks filvrkadma dipghvftri egrdidpksc dkthtcppcp apellggpsv flfppkpkdt lmisrtpevt cvvvdvshed pevkfnwyvd gvevhnaktk preeqynsty rvvsvltvlh qdwlngkeyk ckvsnkalpa piektiskak gqprepqvyt lppsrdeltk nqvsltclvk gfypsdiave wesngqpenn ykttppvlds dgsfflyskl tvdksrwqqg nvfscsvmhe alhnhytqks lslspgkhhh hhh
N-terminal Sequence Analysis
State of Matter
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human IL-18 Rα is Mr 63 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 95-105 kDa.
Predicted Molecular Mass
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
Next Day Ambient
NCBI Gene Bank

References & Citations

1. Huleihel, M. et al. (2008) Am J Reprod Immunol. 60(2):151-9.
2. Wijdenes, J. et al. (2005) Cell Immunol. 236(1-2):101-4.
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
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Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.