Recombinant Human IL-19

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Pricing & Details

Prod. No.I-337
Expression Host
E. coli
Size
Price
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25 µg
349.00
Max:
Min: 1
Step: 1

Background

Interleukin-19 (IL-19) is a secreted protein that belongs to the IL-10 family of cytokines along with several other interleukins including IL-10, IL-20, IL-22, IL-24, IL-26, and several virus-encoded cytokines. Members of this family share partial homology in their amino acid sequences but they are dissimilar in their biological functions. IL-19 is expressed in resting monocytes and B cells and is up-regulated in monocytes following stimulation with granulocyte-macrophage colony-stimulating factor (GM-CSF) or lipopolysaccharide.1 In addition, IL-19 may play important roles in inflammatory responses due to its ability to upregulate IL-6 and TNF-alpha as well as induce apoptosis.2 Human and murine IL-19 share 71% amino acid sequence identity.

Protein Details

Purity
>97% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Biological Activity
The biological activity of Human IL-19 was determined by its ability to induce proliferation of mouse BaF/3 cells co-transfected with human IL-20 Rα and IL-20 Rβ. The expected ED50 for this effect is typically 0.5 - 1.5 ng/mL.
Expression Host
E. coli
Protein Accession No.
Amino Acid Sequence
mlrrcli stdmhhiees fqeikraiqa kdtfpnvtil stletlqiik pldvccvtkn llafyvdrvf kdhqepnpki lrkissians flymqktlrq cqeqrqchcr qeatnatrvi hdnydqlevh aaaikslgel dvflawinkn hevmssa
N-terminal Sequence Analysis
Met
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human IL-19 is Mr 18 kDa.
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
PubMed
NCBI Gene Bank

References & Citations

1. Chang, C. et al. (2003) J. of Biol. Chem. 278:3308
2. Chang, MS. et al. (2002) J. Immunol. 169:4288
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Prod No.
Description
I-871
I-337
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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