TNF-ligand-related molecule 1A (TL1A), is an endothelium-derived T cell costimulator and a ligand for tumor necrosis factor receptor superfamily members DR3 and decoy receptor 3.1 TL1A binds to the death-domain receptor (DR)3 and provides costimulatory signals to activated lymphocytes. Through this interaction, TL1A induces secretion of IFN-γ. Blockade of the TL1A/DR3 pathway may offer therapeutic opportunities in Crohn's disease.2
>95% by SDS-PAGE and analyzed by silver stain.
<0.1 EU/µg as determined by the LAL method
Measured by its ability to induce apoptosis of TF‑1 human erythroleukemic cells.3 The ED50 for this effect is 15-75 ng/mL.
Protein Accession No.
Amino Acid Sequence
iteersepsp qqvyspprgk prahltikkq tpaphlknql salhwehdlg maftkngmky inkslvipes gdyfiysqit frgttsvcgd isrgrrpnkp dsitmvitkv adsypeparl ltgsksvcei snnwfqslyl gatfsleegd rlmvnvsdis lvdytkedkt ffgafll
N-terminal Sequence Analysis
State of Matter
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human TL1-A is Mr 20 kDa.
This rProtein has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 with no calcium, magnesium or preservatives present.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
Next Day Ambient
NCBI Gene Bank
References & Citations
1. Wei, P. et al. (2003) J Biol Chem. 278: 39251
2. Cominelli, F. et al. (2006) PNAS 103: 8441
3. Migone, T. et al. (2002) Immunity 16:479
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.