Recombinant Human TL1-A

TNF-ligand-related molecule 1A (TL1A), is an endothelium-derived T cell costimulator and a ligand for tumor necrosis factor receptor superfamily members DR3 and decoy receptor 3.¹ TL1A binds to the death-domain receptor (DR)3 and provides costimulatory signals to activated lymphocytes. Through this interaction, TL1A induces secretion of IFN-γ. Blockade of the TL1A/DR3 pathway may offer therapeutic opportunities in Crohn's disease.²

Measured by its ability to induce apoptosis of TF‑1 human erythroleukemic cells.³ The ED₅₀ for this effect is 15-75 ng/mL.

AAM77367

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Met

Lyophilized

The predicted molecular weight of Recombinant Human TL1-A is Mr 20 kDa.

This rProtein has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 with no calcium, magnesium or preservatives present.

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

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1. Wei, P. et al. (2003) J Biol Chem. 278: 39251
2. Cominelli, F. et al. (2006) PNAS 103: 8441
3. Migone, T. et al. (2002) Immunity 16:479