Recombinant Human VEGF-D

Vascular endothelial growth factor D (VEGF-D) is a potent angiogenic factor that is a member of the VEGF family¹ that activates VEGF receptor-2.² VEGF-D is also lymphangiogenic, and promotes metastatic spread of tumor cells via lymphatic vessels.³ It may be useful in the treatment of breast cancer as a decision-making biomarker for aggressive treatment after operation.⁴

Lyophilized

The predicted molecular weight of Recombinant Human VEGF-D is Mr 13 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 20-22 kDa.

13

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

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1. Oliviero, S. et al. (1999) Proc Natl Acad Sci USA 96: 9671
2. Stacker, SA. et al. (2000) Eur J Biochem. 267: 2505
3. Achen, MG. et al. (2001) J Biol Chem. 276: 44307
4. Kakudo, K. et al. (2003) Clin Cancer Res. 9: 716