Recombinant Mouse CD86

CD86 is an 80kD Ig superfamily member that is involved in immunoglobulin class-switching and activation of NK cell-mediated cytotoxicity. CD80 is closely related to, and works in tandem with CD86 to prime T- cells. CD86 is expressed earlier in the immune response than CD80. The ligation of CD28 on T cells with CD80 and CD86 on APCs co-stimulates T cells resulting in enhanced cell activation, proliferation, and cytokine production. CD86 can also bind to CTLA-4 to deliver an inhibitory signal to T cells.

The biological activity of Mouse B7-2 was determined by its ability to induce IL-2 secretion by human acute leukemia T cells. The expected ED₅₀=0.05 -0.15 ug/ml in the presence of PHA.

Fc Fusion Protein

vetqa yfngtaylpc pftkaqnisl selvvfwqdq qklvlyehyl gtekldsvna kylgrtsfdr nnwtlrlhnv qikdmgsydc fiqkkpptgs iilqqtltel svianfsepe iklaqnvtgn sginltctsk qghpkpkkmy flitnstney gdnmqisqdn vtelfsisns lslsfpdgvw hmtvvcvlet esmkisskpl nftqefpspq tywkegdieg rmdpkscdkt htcppcpape llggpsvflf ppkpkdtlmi srtpevtcvv vdvshedpev kfnwyvdgve vhnaktkpre eqynstyrvv svltvlhqdw lngkeykckv snkalpapie ktiskakgqp repqvytlpp srdeltknqv sltclvkgfy psdiavewes ngqpennykt tppvldsdgs fflyskltvd ksrwqqgnvf scsvmhealh nhytqkslsl spgk

Val26

Lyophilized

The predicted molecular weight of Recombinant Mouse B7-2 is Mr 51.8 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 60-65 kDa.

51.8

This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient