Recombinant Mouse CCL22

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Pricing & Details

Product. No.M202
Alternate Names
Chemokine (C-C Motif) Ligand 22, MDC, A-152E5.1, ABCD-1, DC/B-CK, MGC34554, SCYA22, STCP-1
Expression Host
E. coli
Species
Mouse
Prod No.
Size
Price
Avail.
Qty
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M202-25 µg
25 µg
$359.00
In stock
Max:
Min: 1
Step: 1

Background

Chemokine (C-C motif) ligand 22, also known as CCL22 is secreted by dendritic cells and macrophages, and elicits its effects on its target cells by interacting with cell surface chemokine receptors such as CCR4.1 CCL22 selectively chemo-attract Th2 cytokine-producing cells2,3 and acts as an important activator of eosinophils once these cells have migrated into tissue.4

Protein Details

Purity
>97% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.01 EU/µg as determined by the LAL method
Biological Activity
The biological activity of Mouse MDC was determined by its ability to chemoattract human T-lymphoblastoid CEM-NKR cells (Howell, D.N. et al., 1985, J. Immunol. 134: 971 - 976) and to chemoattract mouse BaF/3 cells transfected with hCCR4. The expected ED50 for these effects are typically 5 - 20 ng/ml and 0.5 - 3 ng/ml, respectively.
Expression Host
E. coli
Protein Accession No.
Q9QZU2
Amino Acid Sequence
gpyganveds iccqdyirhp lpsrlvkeff wtskscrkpg vvlitvknrd icadprqvwv kkllhkls
N-terminal Sequence Analysis
Gly25
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Mouse CCL22 is Mr 7.8 kDa.
Formulation
This recombinant protein was lyophilized from a 0.2 μm filtered solution in 35% acetonitrile (CH3CN) and 0.1% trifluoroacetic acid (TFA).
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
PubMed
NCBI Gene Bank

References & Citations

1. Sozzani, S. et al. (2001) Eur. J. Immunol. 31:812
2. Elias, CG. et al. (1998) J Immunol. 161:5027
3. Gray, PW. et al. (1997) J Exp Med. 185:1604
4. Teixeira, MM. et al. (2003) J Leuko Biol. 73:356
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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