Recombinant Mouse GDF-5

Growth differentiation factor 5 (cartilage-derived morphogenetic protein-1), also known as GDF5 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. GDF5 is expressed in the developing central nervous system.¹ It increases the survival of neurones that respond to a neurotransmitter called dopamine, and is a potential therapeutic molecule associated with Parkinson's disease.²

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Met and Ala376

Solution

The predicted molecular weight of Recombinant Mouse GDF-5 is Mr 13.7 kDa.

13.7

This recombinant protein was 0.2 µm filtered and is supplied in a solution of 35% acetonitrile (CH₃CN) and 0.1% trifluoroacetic acid (TFA).

Working aliquots of this recombinant protein solution are stable for up to twelve months at -20°C to -70°C in a manual defrost freezer. Upon thawing, in the presence of a carrier protein, this recombinant protein can be stored at 2° - 8°C for one month without detectable loss of activity. For long-term storage, aliquot and freeze at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles.

Next Day 2-8°C

1. Sullivan, A. et al. (2004) J Neurocytol 33: 479
2. O'Keeffe, G. et al. (2005) J Anat 207: 219