Recombinant Mouse IL-17D

Interleukin-17D (IL-17D) is a disulfide-linked homodimer and secreted cytokine with homology to the IL17 family of proteins. The six known members of this family are IL-17A through IL-17F. Two receptors, IL-17 R and IL-17B R, which are activated by IL-17 family members, have been identified (1). IL-17D has the ability to stimulate the production of IL-6, IL-8 and GM-CSF, as well as inhibit hemopoiesis of myeloid progenitor cells in colony forming assays (2). The increased expression of IL-8 induced by this cytokine was found to be NF-κB-dependent. IL-17D is preferentially expressed in skeletal muscle, brain, adipose tissue, heart, lung, and pancreas (2). It is also expressed in resting CD4+ T cells and C19+ B cells (3).

The biological activity of Human IL-17D was determined by its ability to bind rmIL-17B R/Fc in a functional ELISA.

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Ala25

Lyophilized

The predicted molecular weight of Recombinant Human IL-17D is Mr 20 kDa.

This recombinant protein was lyophilized from a 0.2 μm filtered solution in 35% acetonitrile (CH₃CN) and 0.1% trifluoroacetic acid (TFA).

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

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1. Moseley, TA. et al. (2003) Cytokine & Growth Factor Rev. 14:155
2. Starnes, T. et al. (2002) J. Immunol. 169:642
3. Aggarwal, S. et al. (2002) J. Leukoc. Biol. 71:1