Recombinant Mouse IL-17D

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Pricing & Details

Product. No.I-332
Alternate Names
Interleukin-17D, Il27a, AI462269, Il17d
Expression Host
E. coli
Species
Human
Prod No.
Size
Price
Avail.
Qty
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I-332-25 µg
25 µg
$349.00
In stock
Max:
Min: 1
Step: 1

Background

Interleukin-17D (IL-17D) is a disulfide-linked homodimer and secreted cytokine with homology to the IL17 family of proteins. The six known members of this family are IL-17A through IL-17F. Two receptors, IL-17 R and IL-17B R, which are activated by IL-17 family members, have been identified (1). IL-17D has the ability to stimulate the production of IL-6, IL-8 and GM-CSF, as well as inhibit hemopoiesis of myeloid progenitor cells in colony forming assays (2). The increased expression of IL-8 induced by this cytokine was found to be NF-κB-dependent. IL-17D is preferentially expressed in skeletal muscle, brain, adipose tissue, heart, lung, and pancreas (2). It is also expressed in resting CD4+ T cells and C19+ B cells (3).

Protein Details

Purity
>95% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.01 EU/µg as determined by the LAL method
Biological Activity
The biological activity of Human IL-17D was determined by its ability to bind rmIL-17B R/Fc in a functional ELISA.
Expression Host
E. coli
Protein Accession No.
Amino Acid Sequence
alrtgr rparprdcad rpeelleqly grlaagvlsa fhhtlqlgpr eqarnascpa ggraadrrfr pptnlrsvsp wayrisydpa rfprylpeay clcrgcltgl ygeedfrfrs tpvfspavvl rrtaacaggr svyaehyiti pvgctcvpep dksadsanss mdklllgpad rpagr
N-terminal Sequence Analysis
Ala25
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human IL-17D is Mr 20 kDa.
Formulation
This recombinant protein was lyophilized from a 0.2 μm filtered solution in 35% acetonitrile (CH3CN) and 0.1% trifluoroacetic acid (TFA).
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
PubMed
NCBI Gene Bank

References & Citations

1. Moseley, TA. et al. (2003) Cytokine & Growth Factor Rev. 14:155
2. Starnes, T. et al. (2002) J. Immunol. 169:642
3. Aggarwal, S. et al. (2002) J. Leukoc. Biol. 71:1
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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