Recombinant Mouse MIG

Chemokine (C-X-C motif) ligand 9 (CXCL9) is a small cytokine belonging to the CXC chemokine family that is also known as Monokine induced by gamma interferon (MIG). CXCL9 is a T-cell chemoattractant, which is induced by IFN-γ. Mig may be important not only to recruit T cells to peripheral inflammatory sites, but also in some cases to maximize interactions among activated T cells, B cells, and dendritic cells within lymphoid organs to provide optimal humoral responses to pathogens.¹

The biological activity of Mouse MIG was determined by its ability to chemoattract human lymphocytes cultured in the presence of IL-2 for 14 - 21 days, and chemoattract mCXCR3 transfected BaF/3 cells. The expected ED₅₀ for this effect is typically 0.1 - 0.3 μg/ml, and 0.1 – 0.5 μg/ml respectively.

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Thr22

Lyophilized

The predicted molecular weight of Recombinant Mouse MIG is Mr 12kDa.

12

This recombinant protein was lyophilized from a 0.2 μm filtered solution in 30% acetonitrile (CH₃CN) and 0.1% trifluoroacetic acid (TFA).

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

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1. Farber, JM. et al. (2002) J. Immunol. 169: 1433