Recombinant Mouse MSP R

The macrophage stimulating protein receptor (MSP R), also known as RON, is a receptor protein tyrosine kinase of the met/hepatocyte growth factor receptor family. Binding of the macrophage stimulating protein to its receptor provokes changes in cell morphology and motility.¹ Suppressing RON expression and activation decreases cancer cell proliferation and increases apoptotic death. Thus, blocking RON expression and activation has clinical significance in reversing malignant phenotypes and controlling tumor growth.²

Measured by its binding ability in a functional ELISA.

Fc Fusion Protein

stnlnwq cpripyaasr dfsvkyvvps fsaggrvqat aayedstnsa vfvatrnhlh vlgpdlqfie nlttgpignp gcqtcascgp gphgppkdtd tlvlvmepgl palvscgstl qgrcflhele prgkalhlaa paclfsannn kpeactdcva splgtrvtvv eqghasyfyv assldpelaa sfsprsvsir rlksdtsgfq pgfpslsvlp kylasyliky vysfhsgdfv yfltvqpisv tsppsalhtr lvrlnavepe igdyrelvld chfapkrrrr (α subunit) gapegtqpyp vlqaahsapv daklavelsi segqevlfgv fvtvkdggsg mgpnsvvcaf piyhlnilie egveycchss nsssllsrgl dffqtpsfcp nppggeasgp ssrchyfplm vhasftrvdl fngllgsvkv talhvtrlgn vtvahmgtvd grvlqveiar slnyllyvsn fslgssgqpv hrdvsrlgnd llfasgdqvf kvpiqgpgcr hfltcwrclr aqrfmgcgwc gdrcdrqkec pgswqqdhcp peisefyphs gplrgttrlt lcgsnfylrp ddvvpegthq itvgqspcrl lpkdsssprp gslkefiqel eceleplvtq avgttnislv itnmpagkhf rvegisvqeg fsfvepvlts ikpdfgprag gtyltlegqs lsiatsraal vngtqcrleq vneeqilcvt ppgagtarvp lhlqiggaev pgswtfhyke dpivldispk cgysgshimi hgqhltsawh ftlsfhdgqs tvesrcagqf veqqqrrcrl peyvvrnpqg watgnlsvwg dgaagftlpg frflpppspl raglvelkpe ehsvkveyvg lgavadcvtv nmtvggevcq helrgdvvic plppslqlgk dgvplqvcvd ggchilsqvv rsspgrasqr (β subunit) diegrmdpks cdkthtcppc papellggps vflfppkpkd tlmisrtpev tcvvvdvshe dpevkfnwyv dgvevhnakt kpreeqynst yrvvsvltvl hqdwlngkey kckvsnkalp apiektiska kgqprepqvy tlppsrdelt knqvsltclv kgfypsdiav ewesngqpen nykttppvld sdgsfflysk ltvdksrwqq gnvfscsvmh ealhnhytqk slslspgkhh hhhhhh

Ser24 (alpha subunit) & Gly311 (beta subunit)

Lyophilized

The predicted molecular weight of Recombinant Mouse MSP R is Mr 128.7 kDa.

128.7

This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient

1. Breathnach, R. et al. (1995) Biochim Biophys Acta. 1263: 93
2. Zhou, YQ. et al. (2006) Acta Pharmacol Sin. 27: 641