Anti-Mouse MSP R

Product No.: M1267


Target MSP R Product Type Polyclonal Antibody Alternate Names RON (Recepteur D'Origine Nantais), PTK8, STK (Stem Cell-Derived Tyrosine Kinase) Applications N , WB


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Antibody Details Product Details Reactive Species Mouse Host Species Goat Immunogen Purified Recombinant Mouse MSP R (>98%) Endotoxin Level <0.1 EU/µg as determined by the LAL method Formulation This antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 containing 5.0% w/v trehalose with no calcium, magnesium, or preservatives present. State of Matter Lyophilized Storage and Handling The lyophilized antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for twelve months from date of receipt. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months. Country of Origin USA Shipping Next Day Ambient RRIDAB_2831260 Applications and Recommended Usage? Quality Tested by Leinco Western Blotting: To detect Mouse MSP R this polyclonal antibody can be used at a concentration of 0.1-0.2 µg/ml. This polyclonal antibody should be used in conjunction with compatible second-step reagents such as PN:G505 and a chromogenic substrate such as PN:T343. The detection limit for Mouse MSP R is 20 ng/lane under either reducing or non-reducing conditions. The sensitivity of detection may increase up to 50 fold when a chemiluminescent substrate is used. A suitable Western blotting control is PN:M1240. Additional Applications Reported In Literature ? Neutralization: This antibody is useful for neutralization of Mouse MSP R bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Mouse MSP R (at 50 ng/ml) is 0.05-0.2 µg/ml. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. Description Description Specificity Goat Anti-Mouse Macrophage Stimulating Protein Receptor (MSP R) recognizes Mouse MSP R. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research. Background The macrophage stimulating protein receptor (MSP R), also known as RON, is a receptor protein tyrosine kinase of the met/hepatocyte growth factor receptor family. Binding of the macrophage stimulating protein to its receptor provokes changes in cell morphology and motility.¹ Suppressing RON expression and activation decreases cancer cell proliferation and increases apoptotic death. Thus, blocking RON expression and activation has clinical significance in reversing malignant phenotypes and controlling tumor growth.² PubMed MSP R NCBI Gene Bank ID 19882 UniProt.org More Information on Uniprot.org References & Citations 1. Breathnach, R. et al. (1995) Biochim Biophys Acta. 1263: 93 2. Zhou, YQ. et al. (2006) Acta Pharmacol Sin. 27: 641 View product citations for antibody PRODUCT_CODE on CiteAb Technical Protocols N Certificate of Analysis Request COA

Antibody Details

Product Details

Reactive Species

Mouse

Host Species

Goat

Immunogen

Purified Recombinant Mouse MSP R (>98%)

Endotoxin Level

<0.1 EU/µg as determined by the LAL method

Formulation

This antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 containing 5.0% w/v trehalose with no calcium, magnesium, or preservatives present.

State of Matter

Lyophilized

Storage and Handling

The lyophilized antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for twelve months from date of receipt. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.

Country of Origin

USA

Shipping

Next Day Ambient

RRIDAB_2831260

Applications and Recommended Usage?
Quality Tested by Leinco

Western Blotting: To detect Mouse MSP R this polyclonal antibody can be used at a concentration of 0.1-0.2 µg/ml. This polyclonal antibody should be used in conjunction with compatible second-step reagents such as PN:G505 and a chromogenic substrate such as PN:T343. The detection limit for Mouse MSP R is 20 ng/lane under either reducing or non-reducing conditions. The sensitivity of detection may increase up to 50 fold when a chemiluminescent substrate is used. A suitable Western blotting control is PN:M1240.

Additional Applications Reported In Literature ?

Neutralization: This antibody is useful for neutralization of Mouse MSP R bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Mouse MSP R (at 50 ng/ml) is 0.05-0.2 µg/ml.

Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity

Goat Anti-Mouse Macrophage Stimulating Protein Receptor (MSP R) recognizes Mouse MSP R. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.

Background

The macrophage stimulating protein receptor (MSP R), also known as RON, is a receptor protein tyrosine kinase of the met/hepatocyte growth factor receptor family. Binding of the macrophage stimulating protein to its receptor provokes changes in cell morphology and motility.¹ Suppressing RON expression and activation decreases cancer cell proliferation and increases apoptotic death. Thus, blocking RON expression and activation has clinical significance in reversing malignant phenotypes and controlling tumor growth.²

PubMed

MSP R

NCBI Gene Bank ID

19882

UniProt.org

More Information on Uniprot.org