Recombinant Mouse SDF-1α

Recombinant Mouse SDF-1α

Product No.: S501

[product_table name="All Top" skus="S501"]

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Alternate Names
Stromal Cell-Derived Factor-1α, CXCL12, TLSF-a, Pre-B Cell Growth Stimulating Factor (PBSF)
Product Type
Recombinant Protein
Expression Host
E. coli Cells
Species
Mouse

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Background

SDF-1alpha (stromal cell-derived factor-1 alpha) is an alpha-chemokine for haematopoietic stem cells (HSC).1 SDF-1 alpha plays a role in two important processes of granule cell maturation - proliferation and migration - assisting in the achievement of appropriate cell number and position in the cerebellar cortex.2 SDF-1 alpha is also involved in the trafficking of hematopoietic progenitors and stem cells.3 It is expressed by liver cells and in liver diseases.4

Protein Details

Purity
>97% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.01 EU/µg as determined by the LAL method
Biological Activity
The biological activity of Mouse SDF-1α was determined by its ability to chemoattract cultured human lymphocytes, and mouse BaF/3 cells transfected with human CXCR4. The expected ED<sub>50</sub> for this effect is typically 3-9 ng/ml, and 0.15-0.6 ng/ml, respectively.
Protein Accession No.
Amino Acid Sequence
kpvslsyrc pcrffeshia ranvkhlkil ntpncalqiv arlknnnrqv cidpklkwiq eylekalnk
N-terminal Sequence Analysis
Lys22
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Mouse SDF-1α is Mr 8 kDa.
Predicted Molecular Mass
8
Formulation
This recombinant protein was lyophilized from a 0.2 μm filtered solution in 30% acetonitrile (CH3CN) and 0.1% trifluoroacetic acid (TFA).
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient

References & Citations

1. Ratajczak, MZ. et al. (2003) Folia Histochem Cytobiol. 41: 13
2. Luster, AD. et al. (2001) Development 128: 1971
3. Vannier, JP. et al. (2002) Eur Cytokine Netw 12: 223
4. Dickenson, J. et al. (2008) Iran J Allergy Asthma Immunol. 7: 61

Certificate of Analysis

IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.