Recombinant Rat ALK-7

Activin receptor-like kinase (ALK) 7 is a type I serine/threonine kinase receptor of the transforming growth factor (TGF)-beta family of proteins.¹ ALK7 is most abundantly expressed in human brain, pancreas and colon.² It negatively regulates glucose-stimulated insulin release in β-cells³ and plays an important role in regulating the functional plasticity of pancreatic islets.³ ALK7 also has an important role in the regulation of body fat deposition. These has implications for the development of treatments against diabetes and obesity.³

Fc Fusion Protein

NP_620790

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Leu26

Lyophilized

The predicted molecular weight of Recombinant Rat ALK-7 is Mr 35.7 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 47-55 kDa.

35.7

This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient

1. Kim, SJ. et al. (2004) J Biol Chem. 279: 28458 2. Ritvos, O. et al. (2001) Cytogenet Cell Genet. 95: 157 3. Ibanez, CF. et al. (2008) Proc Natl Acad Sci USA 105: 7246