Recombinant Rat ALK-7

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Pricing & Details

Product. No.A345
Alternate Names
Activin Receptor-Like Kinase 7
Expression Host
NS0 cells
Species
Rat
Prod No.
Size
Price
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A345-100 µg
100 µg
$359.00
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Min: 1
Step: 1

Background

Activin receptor-like kinase (ALK) 7 is a type I serine/threonine kinase receptor of the transforming growth factor (TGF)-beta family of proteins.1 ALK7 is most abundantly expressed in human brain, pancreas and colon.2 It negatively regulates glucose-stimulated insulin release in β-cells3 and plays an important role in regulating the functional plasticity of pancreatic islets.3 ALK7 also has an important role in the regulation of body fat deposition. These has implications for the development of treatments against diabetes and obesity.3

Protein Details

Purity
>90% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<1.0 EU/µg as determined by the LAL method
Fusion Protein Tag
Fc Fusion Protein
Expression Host
NS0 cells
Protein Accession No.
NP_620790
Amino Acid Sequence
lkcvc llcdssnftc qtegacwasv mltngkeqvi kscvslpeln aqvfchssnn vtkteccftd fcnnitlhlp taspdaprdi egrmdpkscd kthtcppcpa pellggpsvf lfppkpkdtl misrtpevtc vvvdvshedp evkfnwyvdg vevhnaktkp reeqynstyr vvsvltvlhq dwlngkeykc kvsnkalpap iektiskakg qprepqvytl ppsrdeltkn qvsltclvkg fypsdiavew esngqpenny kttppvldsd gsfflysklt vdksrwqqgn vfscsvmhea lhnhytqksl slspgk
N-terminal Sequence Analysis
Leu26
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Rat ALK-7 is Mr 35.7 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 47-55 kDa.
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
PubMed
NCBI Gene Bank

References & Citations

1. Kim, SJ. et al. (2004) J Biol Chem. 279: 28458 2. Ritvos, O. et al. (2001) Cytogenet Cell Genet. 95: 157 3. Ibanez, CF. et al. (2008) Proc Natl Acad Sci USA 105: 7246
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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