Glial Cell-Line Derived Neurotrophic Factor Receptor Alpha 1 (GDNFR-alpha 1), also known as GFRA1, is a novel glycosylphosphatidylinositol-linked cell surface receptor for glial cell line-derived neurotrophic factor (GDNF)1 that is expressed by Spermatogonial stem cells (SSCs).2 GDNF has been known for many years to protect and restore dopamine neurons of the substantia nigra (SN) in lesion models of parkinsonism.3
>90% by SDS-PAGE and analyzed by silver stain.
<0.1 EU/µg as determined by the LAL method
Fusion Protein Tag
Fc Fusion Protein
Protein Accession No.
Amino Acid Sequence
drldcv kasdqclkeq scstkyrtlr qcvagketnf sltsgleakd ecrsamealk qkslyncrck rgmkkekncl riywsmyqsl qgndlledsp yepvnsrlsd ifravpfisd vfqqvehisk gnncldaaka cnlddtckky rsayitpctt smsnevcnrr kchkalrqff dkvpakhsyg mlfcscrdia cterrrqtiv pvcsyeerer pnclslqdsc ktnyicrsrl adfftncqpe srsvsnclke nyadcllays gligtvmtpn yvdssslsva pwcdcsnsgn dledclkfln ffkdntclkn aiqafgngsd vtmwqpappv qtttatttta frvknkplgp agseneipth vlppcanlqa qklksnvsgs thlclsdsdf gkdglagass hittksmaap pscslcsieg rmdpkscdkt htcppcpape llggpsvflf ppkpkdtlmi srtpevtcvv vdvshedpev kfnwyvdgve vhnaktkpre eqynstyrvv svltvlhqdw lngkeykckv snkalpapie ktiskakgqp repqvytlpp srdeltknqv sltclvkgfy psdiavewes ngqpennykt tppvldsdgs fflyskltvd ksrwqqgnvf scsvmhealh nhytqkslsl spgkhhhhhh
N-terminal Sequence Analysis
State of Matter
Predicted Molecular Mass
The predicted molecular weight of Recombinant Rat GDNF Rα1 is Mr 74 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 95 kDa.
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
Next Day Ambient
NCBI Gene Bank
References & Citations
1. Fox, GM. et al. (1996) Cell 85: 1113 2. Schlatt, S. et al. (2005) Biol Rep. 73: 1011 3. Burke, RE. et al. (2006) J Neural Transmission 70: 41
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.