SERPINH1 (11125P)
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Antibody DetailsProduct DetailsReactive Species Human Product Concentration Lot Specific Formulation Sterile-filtered colorless solution (1mg/ml) in 20mM Tris-HCl, pH 8.0, and 10% glycerol. State of Matter Liquid Storage and Handling Store at 4°C if entire vial will be used within 2-4 weeks. Store at or below - 20°C for longer periods of time. Addition of a carrier protein (such as 0.1% HSA or BSA) is recommended for long-term storage. Country of Origin USA Shipping Next Day 2-8°C Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Recombinant Human SERPINH1 Background SERPINH1 is a member of the serpin superfamily of serine proteinase inhibitors whose expression is induced by heat shock. As a molecular chaperone, it localizes to the endoplasmic reticulum lumen and binds collagen, thus participating in the maturation of collagen molecules, facilitating the folding and assembly of procollagen molecules, retaining unfolded molecules within the ER, and assisting in the transport of correctly folded molecules from the ER to the Golgi apparatus. Autoantibodies to SERPINH1 have been found in cases of rheumatoid arthritis. Function Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. References & CitationsTechnical Protocols Certificate of Analysis |
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