Anti-α-1-antitrypsin Antibody (13703)

Purified human serum alpha-1-antitrypsin.

This monoclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.2 - 7.4 with no carrier protein or preservatives added.

Liquid

Antibodies are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.

Upon initial thawing, appropriately aliquot and store at -80°C. For long-term storage, keep at -80°C. Avoid repeated freeze-thaw cycles.

Next Day 2-8°C

These antibodies specifically recognize human serum alpha-1-antitrypsin. They do not cross-react with alpha-1-antichymotrypsin.

Alpha-1 Antitrypsin (α1AT) is a protease inhibitor of the serpin superfamily. It is generally known as serum trypsin inhibitor and is also referred to as alpha-1 proteinase inhibitor (α1PI) because it inhibits multiple proteases. It protects tissues from proteases of inflammatory cells, particularly neutrophil elastase, and has a reference range in blood of 1.5 - 3.5 gram/liter, but the concentration can rise significantly in cases of acute inflammation. In its absence (such as in α1AT deficiency), neutrophil elastase is free to break down elastin, which contributes to the elasticity of the lungs, resulting in respiratory complications such as emphysema, or COPD (chronic obstructive pulmonary disease) in adults and cirrhosis in adults or children.

Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.; [Short peptide from AAT]: Reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).