Anti-Brain-Derived Neurotrophic Factor (BDNF) Antibody (50170)
Anti-Brain-Derived Neurotrophic Factor (BDNF) Antibody (50170)
Product No.: 50170
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Clone ANT-128 Target Brain-Derived Neurotrophic Factor (BDNF) Formats AvailableView All Product Type Monoclonal Isotype Mouse IgG Applications ELISA |
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Antibody DetailsProduct DetailsReactive Species Human Host Species Mouse Immunogen Recombinant human BDNF Formulation Lyophilized at 1mg/ml in PBS. State of Matter Lyophilized Product Preparation Purified by affinity chromatography Storage and Handling Lyophilized product is stable at 4°C in a dry environment. After reconstitution, store at -20°C. Avoid multiple freeze-thaw cycles. Regulatory Status Research Use Only Country of Origin USA Shipping Next Day 2-8°C Applications and Recommended Usage? Quality Tested by Leinco ELISA: use at 0.1-1ug/ml with BDNF on the solid phase.
These are recommended concentrations. End users should determine optimal concentrations for their applications. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Mouse Monoclonal Antibody specific to Human Brain Derived Neurotrophic Factor Background Brain Derived Neurotrophic Factor (BDNF) is a member of the nerve growth factor family of
proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a
preproprotein that is proteolytically processed to generate the mature protein. Binding of this
protein to its cognate receptor promotes neuronal survival in the adult brain. Expression of this
gene is reduced in Alzheimer's, Parkinson's, and Huntington's disease patients. This gene may
play a role in the regulation of the stress response and in the biology of mood disorders. Function Important signaling molecule that activates signaling cascades downstream of NTRK2 (PubMed:11152678). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. {PubMed:11152678, PubMed:12553913, PubMed:29909994}.; [BDNF precursor form]: Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2 (PubMed:24908487, PubMed:29909994). Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse (By similarity). {UniProtKB:P21237, PubMed:24908487, PubMed:29909994}. NCBI Gene Bank ID UniProt.org Research Area Growth Factors, Cytokines, Receptors References & CitationsTechnical ProtocolsCertificate of Analysis |
Formats Available
