Anti-Brain-Derived Neurotrophic Factor (BDNF) Antibody (50170)

Anti-Brain-Derived Neurotrophic Factor (BDNF) Antibody (50170)

Product No.: 50170

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Clone
ANT-128
Target
Brain-Derived Neurotrophic Factor (BDNF)
Formats AvailableView All
Product Type
Monoclonal
Isotype
Mouse IgG
Applications
ELISA

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Select Product Size
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Antibody Details

Product Details

Reactive Species
Human
Host Species
Mouse
Immunogen
Recombinant human BDNF
Formulation
Lyophilized at 1mg/ml in PBS.
State of Matter
Lyophilized
Product Preparation
Purified by affinity chromatography
Storage and Handling
Lyophilized product is stable at 4°C in a dry environment. After reconstitution, store at -20°C. Avoid multiple freeze-thaw cycles.
Regulatory Status
Research Use Only
Country of Origin
USA
Shipping
Next Day 2-8°C
Applications and Recommended Usage?
Quality Tested by Leinco
ELISA: use at 0.1-1ug/ml with BDNF on the solid phase.

These are recommended concentrations.

End users should determine optimal concentrations for their applications.
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Description

Specificity
Mouse Monoclonal Antibody specific to Human Brain Derived Neurotrophic Factor
Background
Brain Derived Neurotrophic Factor (BDNF) is a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain. Expression of this gene is reduced in Alzheimer's, Parkinson's, and Huntington's disease patients. This gene may play a role in the regulation of the stress response and in the biology of mood disorders.
Function
Important signaling molecule that activates signaling cascades downstream of NTRK2 (PubMed:11152678). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. {PubMed:11152678, PubMed:12553913, PubMed:29909994}.; [BDNF precursor form]: Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2 (PubMed:24908487, PubMed:29909994). Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse (By similarity). {UniProtKB:P21237, PubMed:24908487, PubMed:29909994}.
NCBI Gene Bank ID
UniProt.org
Research Area
Growth Factors, Cytokines, Receptors

References & Citations

Indirect Elisa Protocol

Certificate of Analysis

Formats Available

Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.