Clozapine – BSA Conjugate

Protein in 10 mM phosphate buffered saline, pH 7.2, with 0.01% sodium azide.

Liquid

Clozapine covalently conjugated to bovine serum albumin; supplied in 10 mM PBS, pH 7.2. Purity >95% by SDS-PAGE.

This product is stable when stored at 2-8°C for 5 years if unopened, or -20°C for 5 years. Avoid multiple freeze/thaw cycles.

Research Use Only

2 – 8° C Wet Ice

Competitive ELISA (coating antigen); Lateral Flow (test line)

Recognized by Anti-Clozapine Clone CLO-4718 (C548), which is 100% reactive with clozapine and <1% cross-reactive with aripiprazole, olanzapine, quetiapine, risperidone, ziprasidone, and common tricyclics.

Clozapine, a unique atypical antipsychotic, is primarily employed in the treatment of schizophrenia, particularly in cases resistant to other antipsychotic medications. Introduced in the 1970s, clozapine stands out due to its distinct mechanism of action, primarily antagonizing dopamine receptors, but also influencing other neurotransmitter systems, including serotonin, histamine, and adrenergic receptors. This broad-spectrum modulation contributes to its efficacy in managing symptoms. Notably, clozapine is associated with a risk of agranulocytosis, a potentially life-threatening reduction in white blood cell count. Due to this risk, regular blood monitoring, specifically complete blood cell counts, is crucial for individuals on clozapine therapy. These diagnostic tests are essential for detecting early signs of agranulocytosis, allowing for prompt intervention and ensuring the overall safety and effectiveness of clozapine treatment in patients with severe or treatment-resistant schizophrenia.

Haidary HA, Padhy RK. Clozapine. Treasure Island (FL): StatPearls Publishing; 2024 Jan. Link Text