Anti-CYFRA21-1 Antibody (34083)
Anti-CYFRA21-1 Antibody (34083)
Product No.: 34083
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Clone 1X3 Target CYFRA21-1 Formats AvailableView All Product Type Monoclonal Alternate Names Cytokeratin-19, CK-19, Keratin-19, K19 Isotype Mouse IgG1 Applications ELISA |
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Antibody DetailsProduct DetailsReactive Species Human Host Species Mouse Immunogen Soluble cytokeratin fraction purified from a human cell line Product Concentration Lot Specific Formulation PBS, pH 7.4, 0.09% sodium azide. State of Matter Liquid Product Preparation Purified by ion exchange chromatography Storage and Handling Store product at 4°C. Regulatory Status Research Use Only Country of Origin USA Shipping Next Day 2-8°C Applications and Recommended Usage? Quality Tested by Leinco ELISA: for sandwich ELISA, use #34082 as capture antibody and #34083 as detection antibody.
End users should determine optimal antibody concentrations for their applications. Additional Applications Reported In Literature ? ELISA Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity These antibodies recognize CYFRA21-1. Background CYFRA 21–1 is a fragment of cytokeratin 19 (CK19). CK19 is expressed in the unstratified or pseudostratified epithelium lining the bronchial tree, and overexpression of CK19 has been detected in many lung cancer tissue specimens. Accelerated CK19 degradation occurs in neoplastically transformed epithelial cells as a result of increased protease activity of caspase-3 (a regulator of the apoptosis cascade), and fragments, including CYFRA21-1, are released into the blood. Measurement of levels of serum CYFRA 21–1 is a useful and highly specific auxiliary test for diagnosis of non-small cell lung cancer (NSCLC) as well as for diagnosis of squamous cell carcinoma of the lung. Function Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. {PubMed:16000376}. NCBI Gene Bank ID UniProt.org Research Area Cancer Research References & CitationsTechnical Protocols Certificate of Analysis |
Formats Available
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
