Anti-ESE-1 Antibody (34005)

Anti-ESE-1 Antibody (34005)

Product No.: 34005

- -
- -
Target
ESE-1
Product Type
Polyclonal
Alternate Names
E74-like factor 3, Epithelial-restricted with serine box, Epithelium-restricted Ets protein ESX, Epithelium-specific Ets transcription factor 1, ESE-1
Isotype
Rabbit
Applications
WB,ELISA

- -
- -
Select Product Size
- -
- -

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
N-terminal sequence MAATCEISNIFSNYFS and C-terminal sequence SSGWKEEEVLQSRN of human ESE-1 protein.
Product Concentration
Lot Specific
Formulation
PBS, pH 7.4 with 0.02% sodium azide
State of Matter
Liquid
Product Preparation
Purified by immunoaffinity chromatography
Storage and Handling
This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.
Country of Origin
USA
Shipping
Next Day 2-8°C
Applications and Recommended Usage?
Quality Tested by Leinco
Immunoblotting: use at 1:500-1:1,000 dilution

ELISA: use at 1:1,000-1:5,000 dilution.
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Polyclonal Antibody specific to ESE-1
Background
Epithelium-specific gene regulation plays a critical role during embryogenesis, and the epithelial cell lineage is the first differentiated cell type to appear after fertilization. Until recently, very few epithelial cell-restricted transcription factors had been described. Members of the ets transcription factor/oncogene family have been implicated in human carcinogenesis following the discovery of several distinct chromosomal translocations involving members of the ets family in different types of cancer. ets factors play key roles in transcriptional control of stringently regulated genes, such as genes involved in tissue development, differentiation, angiogenesis, cell cycle control and cell proliferation. ESE-1 is the first member of the ets family that was found to be exclusively expressed and inducible in epithelial cells.

Antigen Details

Function
Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity). {PubMed:10391676, PubMed:10644990, PubMed:10773884, PubMed:11036073, PubMed:11313868, PubMed:12414801, PubMed:12624109, PubMed:12682075, PubMed:12713734, PubMed:14715662, PubMed:14767472, PubMed:15075319, PubMed:15169914, PubMed:15794755, PubMed:16307850, PubMed:17060315, PubMed:9129154, PubMed:9234700, PubMed:9336459, PubMed:9395241, PubMed:9417054}.
NCBI Gene Bank ID
UniProt.org
Research Area
Cancer Research

References & Citations

WB,ELISA
Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.