Anti-FBG4 Antibody (28105)

Product No.: 28105


Target FBG4 Product Type Polyclonal Alternate Names F-box only protein 26 Applications ELISA , WB


Select Product Size 100 µg — $384.00	Qty Max: Min: 1 Step: 1 $384.00 ADD TO CART Login For mAb Advantage Pricing Contact Us for Bulk Quantities


Antibody Details Product Details Reactive Species Human Host Species Rabbit Immunogen Synthetic peptide corresponding to amino acids 70-85 (LQLARDRSAEGRALYA) of human FBG4 conjugated to KLH at the N- terminus. Product Concentration Lot Specific Formulation PBS, pH 7.4. State of Matter Liquid Product Preparation Purified by peptide immuno-affinity chromatography Storage and Handling This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles. Country of Origin USA Shipping Next Day 2-8°C Applications and Recommended Usage? Quality Tested by Leinco Immunoblotting : use at 1:500 dilution. A band of approximately 31 kDa is detected. Positive control: recombinant human full length FBG4 protein. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. Description Description Specificity Rabbit Polyclonal Antibody specific to FBG4 (F Box 4) Background F-box proteins, critical components of the conserved ubiquitin-protein ligase complex SCF (Skp1/Cdc53-Cullin1/F- box), recruit substrates for ubiquitination and consequent degradation through their specific protein-protein interaction domains. Novel human F-box proteins named FBG1, FBG2, FBG3, FBG4 and FBG5 constitute a subfamily of mammalian F-box proteins. FBG genes are expressed in a limited number of human tissues including kidney, liver, brain and muscle tissues. Function Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also recognizes sulfated glycans. Does not bind high-mannose glycoproteins. NCBI Gene Bank ID FBXO17 UniProt.org Q96EF6 Research Area Neuroscience References & Citations Ilyin,GP et al. (2002) Gene 296:11-20. View product citations for antibody PRODUCT_CODE on CiteAb Technical Protocols Certificate of Analysis Request COA

Antibody Details

Product Details

Reactive Species

Human

Host Species

Rabbit

Immunogen

Synthetic peptide corresponding to amino acids 70-85 (LQLARDRSAEGRALYA) of human FBG4 conjugated to KLH at the N- terminus.

Product Concentration

Lot Specific

Formulation

PBS, pH 7.4.

State of Matter

Liquid

Product Preparation

Purified by peptide immuno-affinity chromatography

Storage and Handling

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.

Country of Origin

USA

Shipping

Next Day 2-8°C

Applications and Recommended Usage?
Quality Tested by Leinco

Immunoblotting : use at 1:500 dilution. A band of approximately 31 kDa is detected.

Positive control: recombinant human full length FBG4 protein.

Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity

Rabbit Polyclonal Antibody specific to FBG4 (F Box 4)

Background

F-box proteins, critical components of the conserved ubiquitin-protein ligase complex SCF (Skp1/Cdc53-Cullin1/F- box), recruit substrates for ubiquitination and consequent degradation through their specific protein-protein interaction domains. Novel human F-box proteins named FBG1, FBG2, FBG3, FBG4 and FBG5 constitute a subfamily of mammalian F-box proteins. FBG genes are expressed in a limited number of human tissues including kidney, liver, brain and muscle tissues.

Function

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also recognizes sulfated glycans. Does not bind high-mannose glycoproteins.

NCBI Gene Bank ID

FBXO17

UniProt.org

Q96EF6

Research Area

Neuroscience