Anti-Human BAFF-R (CT)

Anti-Human BAFF-R (CT)

Product No.: B514

[product_table name="All Top" skus="B514"]

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Target
B-Cell Activating Factor
Product Type
Polyclonal Antibody
Alternate Names
TNFRSF13C, BAFF-R, BAFFR, CD268, MGC138235
Applications
ICC
,
IHC FFPE
,
WB

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Antibody Details

Product Details

Reactive Species
Human
Host Species
Rabbit
Immunogen
Purified Recombinant Human BAFF-R (>98%)
Product Concentration
1.0 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Description

Specificity
Rabbit Anti-Human B Cell Activating Factor (BAFF-R) recognizes Human BAFF-R. This polyclonal antibody was purified using affinity chromatography.
Background
Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF, BLyS, TALL-1, THANK, and zTNF4.1-4 BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion.1,2 Two receptors, TACI and BCMA, for BAFF were originally identified. A third receptor was identified recently and designated BAFF-R and BR3 for BLyS receptor 3. Unlike BCMA and TACI, which bind to BAFF and April, BAFF-R/BR3 is specific for BAFF and plays a predominant role in BAFF induced B cell development and survival. BAFF and its receptors are involved in B cell associated autoimmune diseases, and activate NF-kB and c-jun N-terminal kinase.4

References & Citations

1. Moore, P. A. et al. (1999) Science 285:260 2. Schneider, P. et al. (1999) J. Exp. Med. 189:1747 3. Shu, H. B. et al. (1999) J. Leukoc. Biol. 65:680 4. Mukhopadhyay, A. et al. (1999) J. Biol. Chem. 274:15978
ICC
IHC FFPE
General Western Blot Protocol

Certificate of Analysis

Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.