Anti-Human Bim (Intermediate Domain-2)

Anti-Human Bim (Intermediate Domain-2)

Product No.: B460

[product_table name="All Top" skus="B460"]

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Target
Bim
Product Type
Polyclonal Antibody
Alternate Names
BOD
Applications
WB

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Product Size

Data

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Antibody Details

Product Details

Reactive Species
Human
Host Species
Rabbit
Immunogen
PN:B491
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human Bim recognizes an intermediate domain in human, mouse and rat Bim. This polyclonal antibody was purified using affinity chromatography.
Background
Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bim or BOD in human, mouse and rat.1,2 Bim/BOD interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. Bim/BOD induces apoptosis. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines.1,2

Antigen Details

PubMed

References & Citations

1. O'Connor, L. et al. (1998) EMBO J. 17:384-395.
2. Hsu, SY. et al. (1998) Mol. Endocrinol. 12:1432-40.
General Western Blot Protocol
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.