Anti-Human Caspase-3 – DyLight® 755

Anti-Human Caspase-3 – DyLight® 755

Product No.: C1774

[product_table name="All Top" skus="C1774"]

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Clone
C31.129
Target
Caspase-3
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
p17, Caspase-3 Active Subunit
Isotype
IgG1
Applications
FC

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Antibody Details

Product Details

Reactive Species
Human
Host Species
Mouse
Immunogen
Purified Recombinant Human CASP3 (>98%)
Product Concentration
0.1 mg/ml
Formulation
This DyLight<sup>®</sup> 755 conjugate is formulated in 0.01 M phosphate buffered saline (PBS) pH 7.4, 150 mM NaCl, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Handling
This DyLight® 755 conjugate is stable when stored at 2-8°C. Do not freeze.
Country of Origin
USA
Shipping
Next Day 2-8°C
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Mouse Anti-Human Caspase-3 Active Subunit (p17) (CASP3) (Clone C31.129) recognizes an epitope on Human CASP3. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Background
Caspase-3 is a member of the caspase family of cysteine proteases and plays a key role in mediating Fas (CD95) and tumor necrosis factor–1 (TNFR-1) induced apoptosis. Caspases can be divided into three groups: apoptotic initiators, apoptotic executioners, and inflammatory mediators.1,2 Caspase-3 is activated during apoptotic signaling events by upstream proteases including caspase 6 and caspase 8.3 Caspase-3 is thought to be essential for chromatin margination, DNA fragmentation and nuclear collapse during apoptosis.3

Antigen Details

PubMed
NCBI Gene Bank ID

References & Citations

1. Adadah, BA. et al. (2000) Journal of Neurotoma 17(10): 811
2. Salvesen, GS. et al. (1999) Proc. Natl. Acad. Sci. USA 96(20): 10964
3. Slee, EA. et al. (2001) J. Biol. Chem. 276(10):7320
Flow Cytometry

Formats Available

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Products are for research use only. Not for use in diagnostic or therapeutic procedures.