Anti-Human CD19 [Clone SJ25-C1] – PE/Cy5

This conjugate is formulated in phosphate buffered saline (PBS), 1 mg/ml BSA and 10 mM sodium azide as a preservative.

Store at 2-8°C protected from light. DO NOT FREEZE. For long term storage aliquot conjugate into working volumes and store at 2-8°C for up to a year.

Next Day 2-8°C

Clone SJ25-C1 recognizes an epitope on human CD19.

CD19 is a 95 kD transmembrane glycoprotein and member of the Ig superfamily. The antigen serves as an adaptor protein; drawing cytoplasmic signaling proteins to the membrane. It works via the CD19/CD21 complex to decrease the threshold for B cell receptor signaling pathways. Because of its presence on all B cells, CD19 is a biomarker for B lymphocyte development, lymphoma diagnosis and can be utilized as a target for the immunotherapy of lymphoproliferative disorders. Emerging studies indicate that CD19 plays an active role in fueling the growth of these cancers, most notably by stabilizing the concentrations of the MYC oncoprotein, making CD19 an attractive therapeutic target with respect to its downstream signaling.

CD19 is expressed in the majority of Pro-B cells to mature B cells (during development) and follicular dendritic cells. Plasma cells do not express CD19.

Forms complex with CD21 (CR2) and CD81 (TAPA-1), BCR coreceptor

1. Kehrl, J. H. et al. (1994) Immunol. Today 15:432 2. Tedder, T. F. et al. (1994) Immunol. Today 15:437 3. Tedder, T. F. et al. (1989) J. Immunol. 143:712 4. Leukocyte Typing III (1987) Oxford University Press