Anti-Human CD19 – DyLight® 488

Anti-Human CD19 – DyLight® 488

Product No.: C1970

[product_table name="All Top" skus="C1970"]

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Clone
SJ25-C1
Target
CD19
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
Pan B-Cells
Isotype
IgG1
Applications
FC

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Data

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Antibody Details

Product Details

Reactive Species
Human
Host Species
Mouse
Immunogen
NALM1 + NALM16 cells
Product Concentration
0.2 mg/ml
Formulation
This DyLight® 488 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Handling
This DyLight® 488 conjugate is stable when stored at 2-8°C. Do not freeze.
Country of Origin
USA
Shipping
Next Day 2-8°C
Excitation Laser
Blue Laser (493 nm)
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Description

Specificity
Clone SJ25-C1 recognizes an epitope on human CD19.
Background
CD19 is a 95 kD transmembrane glycoprotein and member of the Ig superfamily. The antigen serves as an adaptor protein; drawing cytoplasmic signaling proteins to the membrane. It works via the CD19/CD21 complex to decrease the threshold for B cell receptor signaling pathways. Because of its presence on all B cells, CD19 is a biomarker for B lymphocyte development, lymphoma diagnosis and can be utilized as a target for the immunotherapy of lymphoproliferative disorders. Emerging studies indicate that CD19 plays an active role in fueling the growth of these cancers, most notably by stabilizing the concentrations of the MYC oncoprotein, making CD19 an attractive therapeutic target with respect to its downstream signaling.
Antigen Distribution
CD19 is expressed in the majority of Pro-B cells to mature B cells (during development) and follicular dendritic cells. Plasma cells do not express CD19.
Ligand/Receptor
Forms complex with CD21 (CR2) and CD81 (TAPA-1), BCR coreceptor
PubMed
NCBI Gene Bank ID
Research Area
Costimulatory Molecules
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Immunology

References & Citations

1. Leukocyte Typing III (1987) Oxford University Press: Code No.: 073
2. Leukocyte Typing II (1986) Oxford University Press
Flow Cytometry

Certificate of Analysis

Formats Available

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