Anti-Human CD19 – Purified in vivo GOLD™ Functional Grade

Pricing & Details

Product No.C2854
Clone
SJ25-C1
Protein
CD19
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
CD19 Molecule, Differentiation Antigen CD19, B-Lymphocytes Surface Antigen B4, T-cell Surface Antigen Leu-12, CVID3, B4, B-lymphocyte Antigen CD19
Isotype
Mouse
IgG1 κ
Applications
ELISA
,
FC
Prod No.
Size
Price
Avail.
Qty
Add to cart
C2854-1.0 mg
1.0 mg
$175.00
In stock
Max:
Min: 1
Step: 1
C2854-5.0 mg
5.0 mg
$350.00
In stock
Max:
Min: 1
Step: 1
C2854-25 mg
25 mg
$875.00
In stock
Max:
Min: 1
Step: 1
C2854-50 mg
50 mg
$1,450.00
In stock
Max:
Min: 1
Step: 1
C2854-100 mg
100 mg
$2,125.00
In stock
Max:
Min: 1
Step: 1

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Mouse
Immunogen
NALM1 + NALM16 cells
Product Concentration
≥ 2.0 mg/ml
Endotoxin Level
≤ 1.0 EU/mg as determined by the LAL method
Purity
≥95% monomer by analytical SEC
Formulation
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (PBS) pH 7.2 - 7.4, 150 mM NaCl with no carrier protein, potassium or preservatives added.
Storage and Handling
This antibody is stable for at least four (4) weeks when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day 2-8°C
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Clone SJ25-C1 recognizes an epitope on human CD19.
Antigen Distribution
CD19 is expressed in the majority of Pro-B cells to mature B cells (during development) and follicular dendritic cells. Plasma cells do not express CD19.
Background
CD19 is a 95 kD transmembrane glycoprotein and member of the Ig superfamily. The antigen serves as an adaptor protein; drawing cytoplasmic signaling proteins to the membrane. It works via the CD19/CD21 complex to decrease the threshold for B cell receptor signaling pathways. Because of its presence on all B cells, CD19 is a biomarker for B lymphocyte development, lymphoma diagnosis and can be utilized as a target for the immunotherapy of lymphoproliferative disorders. Emerging studies indicate that CD19 plays an active role in fueling the growth of these cancers, most notably by stabilizing the concentrations of the MYC oncoprotein, making CD19 an attractive therapeutic target with respect to its downstream signaling.

Antigen Details

Protein
Ligand/Receptor
Forms complex with CD21 (CR2) and CD81 (TAPA-1), BCR coreceptor
Function
B cell activation and differentiation
PubMed
NCBI Gene Bank ID
Research Area
Costimulatory Molecules
.
Immunology
Elisa Sandwich Protocol
Flow Cytometry