Anti-Human CD2 [Clone G11] — Alexa Fluor® 647
Anti-Human CD2 [Clone G11] — Alexa Fluor® 647
Product No.: C1835
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Clone G11 Target CD2 Formats AvailableView All Product Type Hybridoma Monoclonal Antibody Alternate Names LFA-2, T11, SRBC-R Isotype Mouse IgG1 κ Applications FC |
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Antibody DetailsProduct DetailsReactive Species Human Host Species Mouse Immunogen Purified Recombinant Human CD2 (>98%) Product Concentration 0.2 mg/ml Formulation This Alexa Fluor® 647 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. Alexa Fluor® is a trademark of Life Technologies Corporation. State of Matter Liquid Storage and Handling This Alexa Fluor® 647 conjugate is stable when stored at 2-8°C. Do not freeze. Regulatory Status Research Use Only Country of Origin USA Shipping 2-8°C Wet Ice Excitation Laser Red Laser (633 nm) Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm. RRIDAB_2828906 Applications and Recommended Usage? Quality Tested by Leinco FC The suggested concentration for this G11 antibody for staining cells in flow cytometry is ≤ 1.0 μg per 106 cells in a volume of 100 μl or 100μl of whole blood. Titration of the reagent is recommended for optimal performance for each application. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Clone G11 recognizes an epitope of human CD2. Background CD2 is a 45-59 kD type I transmembrane glycoprotein belonging to the Ig superfamily. CD2 is the receptor for LFA-3/CD58. CD2 serves as an adhesion receptor that binds to CD58; generating the activation of CD2-positive T cells and NK cells and in the regulation of their cytolytic activities. CD2 is a specific marker for T cells and NK cells. Hence, it can be used in immunohistochemistry to identify the occurrence of these cells in tissue sections. The vast majority of T cell lymphomas and leukemias express CD2 which makes it possible to distinguish these conditions from B-cell lymphomas. Antigen Distribution CD2 is present on normal peripheral blood lymphocytes, thymocytes, mature circulating T-cells and a subset of NK cells. Ligand/Receptor CD58 (LFA-3), CD48, CD59, CD15 PubMed NCBI Gene Bank ID UniProt.org Research Area Costimulatory Molecules . Immunology References & Citations1. Meuer, S.C. et al. (1984) Cell 36:897 2. Peterson, A. and Sneed, B. (1987) Nature 329:842 3. Bierer, B.E. et al.(1989) Annu. Rev Immunol. 7:579 4. Krensky, C.F. et al. (1982) Proc. Natl. Acad. Sci. USA 79:7489 5. Krensky, C.F. et al. (1983) J. Immunol. 131:611 Technical Protocols Certificate of Analysis |
Formats Available
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Prod No. | Description |
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C1839 | |
C109 | |
C111 | |
C110 | |
C1831 | |
C1833 | |
C112 | |
C308 | |
C365 | |
C1835 | |
C965 |
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
