Anti-Human CD6 (Clone 123119)

Product No.: C1446


Clone 123119 Target CD6 Formats AvailableView All Product Type Monoclonal Antibody Alternate Names TP120 Isotype IgG1 Applications WB


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Antibody Details Product Details Reactive Species Human Host Species Mouse Immunogen NS0-Derived Recombinant Human CD6 Extracellular Domain (Accession # CAA43306) Endotoxin Level <0.1 EU/µg as determined by the LAL method Formulation This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present. Storage and Handling The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months. Country of Origin USA Shipping Next Day Ambient RRIDAB_2828508 Applications and Recommended Usage? Quality Tested by Leinco Western Blotting: To detect Human CD6 this monoclonal antibody can be used at a concentration of 1-2 µg/ml. This monoclonal antibody should be used in conjunction with compatible second-step reagents such as PN:M114 and a chromogenic substrate such as PN:T343. The detection limit for Human CD6 is 25 ng/lane under either reducing or non-reducing conditions. The sensitivity of detection may increase up to 50 fold when a chemiluminescent substrate is used. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. Description Description Specificity Mouse Anti-Human Cluster of Differentiation 6 (CD6) (Clone 123119) recognizes an epitope on Human CD6. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. Background CD6 (Cluster of Differentiation 6) is a cell surface glycoprotein that is involved in T cell activation¹ and a member of the scavenger receptor cysteine rich protein superfamily (SRCRSF).² CD6 can deliver coactivating signals to mature T lymphocytes and regulate its antigen specific and autoreactive responses.³ PubMed CD6 NCBI Gene Bank ID 923 UniProt.org Information on Uniprot.org References & Citations 1. Parnes, JR. et al. (1995) Eur J Immunol. 25: 2765 2. Bajorath, J. et al. (1997) Biochemistry 36: 2637 3. Fox, DA. et al. (1996) Immunology 88: 537 View product citations for antibody C1446 on CiteAb Technical Protocols Certificate of Analysis Request COA

Antibody Details

Product Details

Reactive Species

Human

Host Species

Mouse

Immunogen

NS0-Derived Recombinant Human CD6 Extracellular Domain (Accession # CAA43306)

Endotoxin Level

<0.1 EU/µg as determined by the LAL method

Formulation

This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.

Storage and Handling

The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.

Country of Origin

USA

Shipping

Next Day Ambient

RRIDAB_2828508

Applications and Recommended Usage?
Quality Tested by Leinco

Western Blotting: To detect Human CD6 this monoclonal antibody can be used at a concentration of 1-2 µg/ml. This monoclonal antibody should be used in conjunction with compatible second-step reagents such as PN:M114 and a chromogenic substrate such as PN:T343. The detection limit for Human CD6 is 25 ng/lane under either reducing or non-reducing conditions. The sensitivity of detection may increase up to 50 fold when a chemiluminescent substrate is used.

Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity

Mouse Anti-Human Cluster of Differentiation 6 (CD6) (Clone 123119) recognizes an epitope on Human CD6. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Background

CD6 (Cluster of Differentiation 6) is a cell surface glycoprotein that is involved in T cell activation¹ and a member of the scavenger receptor cysteine rich protein superfamily (SRCRSF).² CD6 can deliver coactivating signals to mature T lymphocytes and regulate its antigen specific and autoreactive responses.³

PubMed

CD6

NCBI Gene Bank ID

923

UniProt.org

Information on Uniprot.org

References & Citations

1. Parnes, JR. et al. (1995) Eur J Immunol. 25: 2765
2. Bajorath, J. et al. (1997) Biochemistry 36: 2637
3. Fox, DA. et al. (1996) Immunology 88: 537

View product citations for antibody C1446 on CiteAb

Certificate of Analysis

Request COA

Prod No.	Description
C1446	Anti-Human CD6 (Clone 123119)
C1454	Anti-Mouse CD6
C1471	Anti-Human CD6
C1348	Recombinant Human CD6
C1353	Recombinant Mouse CD6
C1516	Anti-Human CD6-Biotin

Formats Available

Prod No.	Description
C1446	Anti-Human CD6 (Clone 123119)

Products are for research use only. Not for use in diagnostic or therapeutic procedures.

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Anti-Human CD6 (Clone 123119)