Antibody DetailsProduct DetailsReactivity Species Human Host Species Mouse Immunogen NS0-Derived Recombinant Human CD6 Extracellular Domain (Accession # CAA43306) Endotoxin Level <0.1 EU/µg as determined by the LAL method Formulation This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present. Storage and Handling The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months. Country of Origin USA Shipping Next Day Ambient RRIDAB_2828508 Applications and Recommended Usage? Quality Tested by Leinco Western Blotting: To detect Human CD6 this monoclonal antibody can be used at a concentration of 1-2 µg/ml. This monoclonal antibody should be used in conjunction with compatible second-step reagents such as PN:M114 and a chromogenic substrate such as PN:T343. The detection limit for Human CD6 is 25 ng/lane under either reducing or non-reducing conditions. The sensitivity of detection may increase up to 50 fold when a chemiluminescent substrate is used. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity Mouse Anti-Human Cluster of Differentiation 6 (CD6) (Clone 123119) recognizes an epitope on Human CD6. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. Background CD6 (Cluster of Differentiation 6) is a cell surface glycoprotein that is involved in T cell activation1 and a member of the scavenger receptor cysteine rich protein superfamily (SRCRSF).2 CD6 can deliver coactivating signals to mature T lymphocytes and regulate its antigen specific and autoreactive responses.3 Antigen DetailsProtein PubMed NCBI Gene Bank ID UniProt.org References & Citations1. Parnes, JR. et al. (1995) Eur J Immunol. 25: 2765 2. Bajorath, J. et al. (1997) Biochemistry 36: 2637 3. Fox, DA. et al. (1996) Immunology 88: 537 Technical Protocols |
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