Anti-Human DNase II (CT)

Pricing & Details

Product No.D245
Protein
DNase II
Formats AvailableView All
Product Type
Polyclonal Antibody
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
D245-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
D245-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:D273
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human DNase II recognizes an epitope near the C-terminus of Human DNase II. This polyclonal antibody was purified using affinity chromatography.
Background
Apoptosis is characterized by several morphological nuclear changes including chromatin condensation and nuclear fragmentation. These changes are triggered by the activation of members of caspase family, caspase activated DNase, and several novel proteins including AIF and Acinus . DNase II causes both chromatin condensation and DNA fragmentation . The genes encoding human,2,4 porcine,4 and murine5 DNase II have been cloned. The DNase II gene encodes a 40 kDa proenzyme. The mature enzyme consists of two non-identical subunits, the 32 kDa (a) and 12 kDa (b) chains, generated by proteolytic processing. Overexpression of DNase II induces chromatin condensation.3 DNase II is ubiquitously expressed in human tissues.

Antigen Details

Protein
PubMed

References & Citations

1. Zamzami, N. and Kroemer, G. (1999) Nature 401:127-8
2. Yasuda, T. et al. (1998) J Biol Chem 273:2610-6
3. Krieser, RJ. and Eastman, A. (1998) J Biol Chem 273:30909-14
4. Shiokawa, D. and Tanuma, S. (1998) Biochem Biophys Res Commun 247:864-9
IHC
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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