Anti-Human Endostatin N-Terminal (a.a.1-12)

Home/Primary Monoclonal Antibodies/Apoptosis & Cell Biology/Anti-Human Endostatin N-Terminal (a.a.1-12)

Pricing & Details

Product No.E131
Clone
NE1.479
Protein
Endostatin
Formats AvailableView All
Product Type
Monoclonal Antibody
Isotype
Mouse
IgG1
Applications
ELISA Indirect
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
E131-0.1 mg
0.1 mg
$254.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Mouse
Immunogen
A peptide corresponding to amino acids 1-12
Product Concentration
0.5 mg/ml
Formulation
This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Handling
This purified antibody is stable when stored at 2-8°C. Do not freeze.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Mouse Anti-Human Endostatin (Clone NE1.479) recognizes Human Endostatin and does not appear to cross-react with Mouse Endostatin. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Background
Endostatin is globular domain found at the C-terminal derived from type XVIII collagen. It serves as an anti-angiogenic agent, similar to angiostatin and thrombospondin. It is an angiogenesis inhibitor and may interfere with the pro-angiogenic action of growth factors such as basic fibroblast growth factor (bFGF/FGF-2) and vascular endothelial growth factor (VEGF). 1
On the surface of endothelial cells, endostatin binds with the integrin alpha(5)beta(1) that activates the Src-kinase pathway. The binding of endostatin with integrins also down-regulates the activity of RhoA GTPase and inhibits signaling pathways mediated by small kinases of the Ras and Raf families. All these events promote disassembly of the actin cytoskeleton, disorders in cell-matrix interactions, and decrease in endotheliocyte mobility, i.e., promote the suppression of angiogenesis. 2 Endostatin is currently being studied as part of cancer research.

Antigen Details

Protein
Research Area
Apoptosis
.
Cell Biology
.
Immunology

References & Citations

1. Ponnazhagan, S. et al. (2017) FASEB J. 31(4):1608-1619. PubMed
2. Folkman, J. et al. (2006) Exp. Cell. Res. 312: 594
3. Severin, SE. et al. (2007) Biochemistry (Mosc). 72: 235
Indirect Elisa Protocol
General Western Blot Protocol
Prod No.
Description
E187

Formats Available

Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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