Anti-Human Hepsin (Clone 3H10.1) – Purified

Anti-Human Hepsin (Clone 3H10.1) – Purified

Product No.: H5510

[product_table name="All Top" skus="C163"]

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Clone
3H10.1
Target
Hepsin
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
HPN, TMPRSS1, 3H10.1.2
Isotype
IgG1 κ
Applications
ELISA
,
FC

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Product Size
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Antibody Details

Product Details

Reactive Species
Human/Hamster/Primate
Host Species
Mouse
Immunogen
Human hepsin protein
Product Concentration
0.5 mg/ml
Formulation
This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Handling
This purified antibody is stable when stored at 2-8°C. Do not freeze.
Country of Origin
USA
Shipping
Next Day 2-8°C
Applications and Recommended Usage?
Quality Tested by Leinco
ELISA
FC
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Clone 3H10.1.2 is able to recognize full-length native Hepsin expressed on the cell surface in addition to the recombinant soluble form. Clones 3H1.1.1 and 1F2.1.1 bind to the same epitope as clone 3H10.1.2 and inhibit it (and each other) from binding Hepsin. Clone 3H10.1.2 and clone 2D5.1.9 bind separate epitopes and do not inhibit each other from binding Hepsin.
Antigen Distribution
Hepsin is expressed on the surface of epithelial cells including the liver, kidney, prostate, and thyroid in human tissues.
Background
Hepsin is a type II transmembrane serine protease (TTSP) expressed on the surface of epithelial cells including the liver, kidney, prostate, and thyroid in human tissues. The physiological function of hepsin is unclear, although, In vitro studies have shown that hepsin activates blood clotting factors VII, XII, and IX, pro-urokinase (pro-uPA), and pro-hepatocyte growth factor (pro-HGF). The over-expression of hepsin has been implicated in several types of cancer, especially ovarian and prostate, which makes it an attractive diagnostic marker for cancers. Most notably, hepsin has been identified as one of the most highly induced genes in prostate cancer, and this over-expression is correlated with the cancer progression and metastasis. Furthermore anti-hepsin antibodies have been shown to inhibit the invasion of human prostate cancer cells.1

Antigen Details

PubMed
NCBI Gene Bank ID
Research Area
Immuno-Oncology

References & Citations

1. Wu,Q. and Parry, G. (2007) Front Biosci 12 5052-9
2. Kirchhofer, D. et al. (2006) J Biol Chem.281(41):30439-46.
Indirect Elisa Protocol
Flow Cytometry

Formats Available

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Products are for research use only. Not for use in diagnostic or therapeutic procedures.